Wwp2 - WW domain containing E3 ubiquitin protein ligase 2 Gene

Mus musculus

Also known as AIP2; 1300010O06Rik

Gene ID: 66894 | Gene type: protein coding

About Wwp2

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and ubiquitin protein Ligase activity. Involved in cellular protein metabolic process and regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including heart valve; respiratory system; sensory organ; skeleton; and tarsus. Orthologous to human WWP2 (WW domain containing E3 ubiquitin protein Ligase 2). [provided by Alliance of Genome Resources, Apr 2022]

Wwp2 Products(1)

mRNA	Protein	Name
NM_025830.4	NP_080106.1	NEDD4-like E3 ubiquitin-protein ligase WWP2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IGI IGI: Inferred from genetic interaction	21427722	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	15047715	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21427722	MGI
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	15047715	MGI
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19997087	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	15047715	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15047715	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15047715	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21427722	MGI
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19997087	MGI
involved in protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	19997087	MGI
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	15047715	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	21427722	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15047715	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15047715	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

NEDD4-like E3 ubiquitin-protein ligase WWP2

HECT-type E3 ubiquitin transferase WWP2	WW domain-containing protein 2
WW domain-containing protein 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-134417	NSC2805	Inhibitor	99.42%	Unkown
HY-168601	WWP1/2-IN-1	Inhibitor	/	Unkown
HY-RS15861	WWP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18265	Wwp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24744	Wwp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Wwp2	NCBI	NCBI:11060

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