2. Gene
  3. Uba5 - ubiquitin-like modifier activating enzyme 5 Gene

Uba5 - ubiquitin-like modifier activating enzyme 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Ube1dc1; 5730525G14Rik

Gene ID: 66663 | Gene type: protein coding

About Uba5

Summary

Enables UFM1 activating enzyme activity. Involved in erythrocyte differentiation; megakaryocyte differentiation; and protein ufmylation. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol. Is expressed in liver. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 24 and developmental and epileptic encephalopathy 44. Orthologous to human UBA5 (ubiquitin like modifier activating enzyme 5). [provided by Alliance of Genome Resources, Apr 2022]

Uba5 Products(1)

mRNA Protein Name
NM_025692.3 NP_079968.2 ubiquitin-like modifier-activating enzyme 5
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables UFM1 activating enzyme activity IDA
IDA: Inferred from direct assay
21304510 MGI
enables UFM1 activating enzyme activity IMP
IMP: Inferred from mutant phenotype
20018847 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
21304510 MGI
Biological Process GO Annotation Evidence Reference Source
involved in erythrocyte differentiation IMP
IMP: Inferred from mutant phenotype
21304510 MGI
involved in megakaryocyte differentiation IMP
IMP: Inferred from mutant phenotype
21304510 MGI
involved in protein ufmylation IDA
IDA: Inferred from direct assay
20018847 MGI
involved in protein ufmylation IMP
IMP: Inferred from mutant phenotype
33372156 MGI
involved in regulation of type II interferon production IMP
IMP: Inferred from mutant phenotype
33372156 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin-like modifier-activating enzyme 5

UFM1-activating enzyme

ubiquitin-activating enzyme 5

ubiquitin-activating enzyme E1 domain-containing protein 1

ubiquitin-activating enzyme E1-domain containing 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101836 DKM 2-93 Inhibitor 98.76% Unkown
HY-148266 UBA5-IN-1 Inhibitor ≥98.0% Unkown
HY-RS15322 UBA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18051 Uba5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24525 Uba5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Uba5 NCBI NCBI:79876