2. Gene
  3. Mcm8 - minichromosome maintenance 8 homologous recombination repair factor Gene

Mcm8 - minichromosome maintenance 8 homologous recombination repair factor Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 5730432L01Rik

Gene ID: 66634 | Gene type: protein coding

About Mcm8

Summary

Predicted to enable several functions, including chromatin binding activity; mismatch repair complex binding activity; and single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in double-strand break repair via homologous recombination; female gamete generation; and male gamete generation. Part of MCM8-MCM9 complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and vibrissa. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 10. Orthologous to human MCM8 (minichromosome maintenance 8 homologous recombination repair factor). [provided by Alliance of Genome Resources, Apr 2022]

Mcm8 Products(2)

mRNA Protein Name
NM_001291054.1 NP_001277983.1 DNA helicase MCM8 isoform a
NM_025676.4 NP_079952.2 DNA helicase MCM8 isoform b
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
22771120 MGI
involved in double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
22771120 MGI
involved in female gamete generation IMP
IMP: Inferred from mutant phenotype
22771120 MGI
involved in male gamete generation IMP
IMP: Inferred from mutant phenotype
22771120 MGI
Cellular Component GO Annotation Evidence Reference Source
part of MCM8-MCM9 complex IDA
IDA: Inferred from direct assay
22771120 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA helicase MCM8

DNA replication licensing factor MCM8

minichromosome maintenance deficient 8

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08241 MCM8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22231 Mcm8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28753 Mcm8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mcm8 NCBI NCBI:84515