2. Gene
  3. Lamtor1 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Gene

Lamtor1 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p18; Pdro; 2400001E08Rik

Gene ID: 66508 | Gene type: protein coding

About Lamtor1

Summary

Predicted to enable GTPase binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including lysosome localization; positive regulation of MAPK cascade; and regulation of receptor recycling. Predicted to be located in late endosome membrane and membrane raft. Predicted to be part of Ragulator complex. Predicted to be active in lysosome. Is expressed in several structures, including adipose tissue; alimentary system; early conceptus; nervous system; and reproductive system. Orthologous to human LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and mTOR Activator 1). [provided by Alliance of Genome Resources, Apr 2022]

Lamtor1 Products(1)

mRNA Protein Name
NM_025605.3 NP_079881.2 ragulator complex protein LAMTOR1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19177150 MGI
enables protein-membrane adaptor activity IDA
IDA: Inferred from direct assay
30020076 MGI
Biological Process GO Annotation Evidence Reference Source
involved in endosomal transport IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in lysosome localization IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in lysosome organization IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
30020076 MGI
involved in protein localization IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in protein localization to membrane IDA
IDA: Inferred from direct assay
30020076 MGI
involved in regulation of receptor recycling IMP
IMP: Inferred from mutant phenotype
19177150 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
30020076 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ragulator complex protein LAMTOR1

RhoA activator C11orf59 homolog

late endosomal/lysosomal adaptor and MAPK and MTOR activator 1

lipid raft adaptor protein p18

p27Kip1-releasing factor from RhoA

p27RF-Rho

ragulator complex protein PDRO

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-176166 PD-M6 Degrader / Unkown
HY-RS07513 LAMTOR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20212 Lamtor1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26717 Lamtor1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lamtor1 NCBI NCBI:55004