Spc25 - SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) Gene

Mus musculus

Also known as Spbc25; 2600017H08Rik; 2610205L13Rik

Gene ID: 66442 | Gene type: protein coding

About Spc25

Summary

This gene encodes a component of the kinetochore-associated NDC80 protein complex, which is required for the mitotic spindle checkpoint and for microtubule-kinetochore attachment. During meiosis in mouse, the protein localizes to the germinal vesicle and then is associated with the chromosomes following germinal vesicle breakdown. Knockdown of this gene in oocytes results in precocious polar body extrusion, chromosome misalignment and aberrant spindle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Spc25 Products(4)

mRNA	Protein	Name
NM_001199123.2	NP_001186052.1	kinetochore protein Spc25 isoform 1
NM_001199124.2	NP_001186053.1	kinetochore protein Spc25 isoform 1
NM_001305800.1	NP_001292729.1	kinetochore protein Spc25 isoform 1
NM_025565.4	NP_079841.1	kinetochore protein Spc25 isoform 2

Protein Preferred Names

Protein Names

kinetochore protein Spc25

spindle pole body component 25 homolog

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13648	SPC25 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21766	Spc25 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Spc25	NCBI	NCBI:57405

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