Klf15 - Kruppel-like factor 15 Gene

Mus musculus

Also known as CKLF; KKLF; hlb444; 1810013I09Rik

Gene ID: 66277 | Gene type: protein coding

About Klf15

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in cardiac muscle hypertrophy in response to stress; glomerular visceral epithelial cell differentiation; and negative regulation of peptidyl-lysine acetylation. Acts upstream of or within several processes, including cellular glucose homeostasis; positive regulation of glucose import; and response to Insulin. Located in nucleus. Is expressed in several structures, including central nervous system; cranium; early conceptus; metanephros; and nose. Used to study aortic aneurysm. Orthologous to human KLF15 (Kruppel like factor 15). [provided by Alliance of Genome Resources, Apr 2022]

Klf15 Products(2)

mRNA	Protein	Name
NM_001355668.1	NP_001342597.1	Krueppel-like factor 15 isoform 2
NM_023184.4	NP_075673.1	Krueppel-like factor 15 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12097321	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12097321	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12097321	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	22367544	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle hypertrophy in response to stress	IMP IMP: Inferred from mutant phenotype	17438289	MGI
acts upstream of or within glial cell differentiation	IDA IDA: Inferred from direct assay	19741146	MGI
acts upstream of or within intracellular glucose homeostasis	IDA IDA: Inferred from direct assay	12097321	MGI
involved in negative regulation of peptidyl-lysine acetylation	IMP IMP: Inferred from mutant phenotype	20375365	MGI
involved in podocyte differentiation	IMP IMP: Inferred from mutant phenotype	22493483	MGI
acts upstream of or within positive regulation of D-glucose import	IDA IDA: Inferred from direct assay	12097321	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12097321	MGI
acts upstream of or within regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	31582141	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	31582141	MGI
involved in regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17438289	MGI
acts upstream of or within response to insulin	IDA IDA: Inferred from direct assay	12097321	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	12097321	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

Krueppel-like factor 15

cardiovascular Krueppel-like factor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07336	KLF15 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18393	Klf15 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24874	Klf15 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Klf15	NCBI	NCBI:28999

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