Abhd6 - abhydrolase domain containing 6 Gene

Mus musculus

Also known as 0610041D24Rik

Gene ID: 66082 | Gene type: protein coding

About Abhd6

Summary

Enables acylglycerol Lipase activity and Phospholipase activity. Involved in several processes, including monoacylglycerol catabolic process; negative regulation of cold-induced thermogenesis; and phospholipid metabolic process. Acts upstream of or within long-term synaptic depression; negative regulation of cell migration; and regulation of endocannabinoid signaling pathway. Located in late endosome membrane; lysosomal membrane; and mitochondrion. Is integral component of postsynaptic membrane. Part of AMPA glutamate receptor complex. Is active in GABA-ergic synapse and glutamatergic synapse. Orthologous to human ABHD6 (abhydrolase domain containing 6, acylglycerol Lipase). [provided by Alliance of Genome Resources, Apr 2022]

Abhd6 Products(3)

mRNA	Protein	Name
NM_001331064.1	NP_001317993.1	monoacylglycerol lipase ABHD6 isoform 1
NM_001331065.1	NP_001317994.1	monoacylglycerol lipase ABHD6 isoform 2
NM_025341.4	NP_079617.2	monoacylglycerol lipase ABHD6 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables monoacylglycerol lipase activity	IDA IDA: Inferred from direct assay	18096503	MGI
enables monoacylglycerol lipase activity	IMP IMP: Inferred from mutant phenotype	20657592	MGI
enables phospholipase activity	IDA IDA: Inferred from direct assay	24095738	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in acylglycerol catabolic process	IDA IDA: Inferred from direct assay	18096503	MGI
acts upstream of or within long-term synaptic depression	IMP IMP: Inferred from mutant phenotype	20657592	MGI
involved in lysobisphosphatidic acid metabolic process	IDA IDA: Inferred from direct assay	26491015	MGI
involved in monoacylglycerol catabolic process	IDA IDA: Inferred from direct assay	26491015	MGI
acts upstream of or within negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20657592	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	26997277	MGI
involved in phospholipid catabolic process	IDA IDA: Inferred from direct assay	24095738	MGI
involved in positive regulation of lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	24095738	MGI
acts upstream of or within regulation of endocannabinoid signaling pathway	IMP IMP: Inferred from mutant phenotype	20657592	MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid	EXP EXP: Inferred from Experiment	20657592	MGI
involved in regulation of retrograde trans-synaptic signaling by endocanabinoid	IDA IDA: Inferred from direct assay	20657592	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of AMPA glutamate receptor complex	IDA IDA: Inferred from direct assay	22632720	MGI
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	20657592	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	20657592	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	20657592	MGI
located in late endosome membrane	IDA IDA: Inferred from direct assay	26491015	MGI
located in lysosomal membrane	IDA IDA: Inferred from direct assay	26491015	MGI
located in membrane	IDA IDA: Inferred from direct assay	18096503	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	20657592	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	20657592	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

monoacylglycerol lipase ABHD6

2-arachidonoylglycerol hydrolase

Related Agents

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100337	WWL70	Inhibitor	99.95%	Unkown
HY-110148	WWL113	Inhibitor	99.72%	Unkown
HY-120215	KT203	Inhibitor	99.86%	Unkown
HY-136924	FP-Biotin		99.84%	Unkown
HY-120177	KT182	Inhibitor	99.93%	Unkown
HY-125143	ABC34	Inhibitor	99.90%	Unkown
HY-114926	KT185	Inhibitor	99.30%	Unkown
HY-101457	JZP-430	Inhibitor	99.74%	Unkown
HY-152148	JZP-MA-11	Inhibitor	99.26%	Unkown
HY-132310	MAGL-IN-4	Inhibitor	99.91%	Unkown
HY-121422	JZP-361	Inhibitor	99.72%	Unkown
HY-132246	WWL123 analogue-1	Inhibitor	98.04%	Unkown
HY-18544	AA38-3	Inhibitor	99.89%	Unkown
HY-103463	SA57	Inhibitor	≥99.0%	Unkown
HY-110178	WWL123	Inhibitor	≥98.0%	Unkown
HY-116212	JCP-170	Inhibitor	/	Unkown
HY-116793	Dimepiperate		/	Unkown
HY-120171	DH-376	Inhibitor	/	Unkown
HY-124314	LEI-106	Inhibitor	/	Unkown
HY-126031	(R)-KT109	Inhibitor	/	Unkown
HY-152152	JZP-MA-13	Inhibitor	/	Unkown
HY-158338	ABHD antagonist 1	Antagonist	/	Unkown
HY-158339	ABHD antagonist 2	Antagonist	/	Unkown
HY-RS00097	ABHD6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-126031A	(S)-KT109		/	Unkown
HY-RS16727	Abhd6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23163	Abhd6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abhd6	NCBI	NCBI:57406

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