1. Gene
  2. Tctn1 - tectonic family member 1 Gene

Tctn1 - tectonic family member 1 Gene

Mus musculus

Also known as Tect1; 4930565B19Rik; G730031O11Rik

Gene ID: 654470 | Gene type: protein coding

About Tctn1

Summary

Involved in cilium assembly and protein localization to ciliary transition zone. Acts upstream of or within in utero embryonic development; nervous system development; and regulation of smoothened signaling pathway. Located in ciliary transition zone; extracellular space; and membrane. Part of MKS complex. Is expressed in several structures, including gut epithelium; neural tube; node; notochord; and somite. Human ortholog(s) of this gene implicated in Joubert syndrome 13. Orthologous to human TCTN1 (tectonic family member 1). [provided by Alliance of Genome Resources, Apr 2022]

Tctn1 Products(1)

mRNA Protein Name
NM_001039153.3 NP_001034242.2 tectonic-1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21565611 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within central nervous system interneuron axonogenesis IMP
IMP: Inferred from mutant phenotype
16357211 MGI
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
21725307 MGI
acts upstream of or within dorsal/ventral neural tube patterning IMP
IMP: Inferred from mutant phenotype
16357211 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
16357211 MGI
acts upstream of or within neural tube formation IMP
IMP: Inferred from mutant phenotype
16357211 MGI
involved in protein localization to ciliary transition zone IMP
IMP: Inferred from mutant phenotype
26982032 MGI
acts upstream of or within regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
16357211 MGI
acts upstream of or within somatic motor neuron differentiation IMP
IMP: Inferred from mutant phenotype
16357211 MGI
acts upstream of or within telencephalon development IMP
IMP: Inferred from mutant phenotype
16357211 MGI
Cellular Component GO Annotation Evidence Reference Source
part of MKS complex IDA
IDA: Inferred from direct assay
21725307 MGI
located in ciliary transition zone IMP
IMP: Inferred from mutant phenotype
21725307 MGI
located in extracellular space IDA
IDA: Inferred from direct assay
16357211 MGI
located in membrane IDA
IDA: Inferred from direct assay
22179047 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tectonic-1

Orthologs Information

Species Symbol Source ID
Homo sapiens Tctn1 NCBI NCBI:79600