Kcnn4 - potassium calcium-activated channel subfamily N member 4 Gene

Rattus norvegicus

Also known as rSK4; KCa3.1; rKCNN4c

Gene ID: 65206 | Gene type: protein coding

About Kcnn4

Summary

Enables Intermediate conductance calcium-activated Potassium Channel activity. Involved in anion transport and potassium ion export across plasma membrane. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and membrane raft. Human ortholog(s) of this gene implicated in dehydrated hereditary stomatocytosis 2. Orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4). [provided by Alliance of Genome Resources, Apr 2022]

Kcnn4 Products(4)

mRNA	Protein	Name
NM_001270701.1	NP_001257630.1	intermediate conductance calcium-activated potassium channel protein 4 isoform a
NM_001270702.1	NP_001257631.1	intermediate conductance calcium-activated potassium channel protein 4 isoform b
NM_001270703.1	NP_001257632.1	intermediate conductance calcium-activated potassium channel protein 4 isoform c
NM_023021.2	NP_075410.2	intermediate conductance calcium-activated potassium channel protein 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables intermediate conductance calcium-activated potassium channel activity	IDA IDA: Inferred from direct assay	10532960	RGD
enables inward rectifier potassium channel activity	IDA IDA: Inferred from direct assay	21463632	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	25715999	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	26439051	RGD
involved in hepatocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	27354175	RGD
involved in monoatomic anion transport	IDA IDA: Inferred from direct assay	20616305	RGD
involved in mononuclear cell migration	IMP IMP: Inferred from mutant phenotype	25715999	RGD
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	28679649	RGD
involved in negative regulation of cell volume	IMP IMP: Inferred from mutant phenotype	27354175	RGD
involved in negative regulation of hepatic stellate cell proliferation	IMP IMP: Inferred from mutant phenotype	27354175	RGD
involved in positive regulation of G0 to G1 transition	IMP IMP: Inferred from mutant phenotype	26439051	RGD
involved in positive regulation of microglial cell activation	IMP IMP: Inferred from mutant phenotype	21750563	RGD
involved in positive regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	28679649	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	24312257	RGD
involved in potassium ion export across plasma membrane	IDA IDA: Inferred from direct assay	12606302	RGD
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	10532960	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	10532960	RGD
involved in regulation of angiotensin levels in blood	IMP IMP: Inferred from mutant phenotype	25715999	RGD
involved in regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	25715999	RGD
involved in regulation of renin secretion into blood stream	IMP IMP: Inferred from mutant phenotype	25715999	RGD
involved in regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	26439051	RGD
involved in regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	25715999	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	28679649	RGD
involved in response to insulin	IEP IEP: Inferred from expression pattern	21463632	RGD
involved in response to tetrachloromethane	IEP IEP: Inferred from expression pattern	27354175	RGD
involved in vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	21463632	RGD
involved in vascular associated smooth muscle cell proliferation	IEP IEP: Inferred from expression pattern	21463632	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12606302	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12606302	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15680700	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

intermediate conductance calcium-activated potassium channel protein 4

IK1	KCa4
SK4	SKCa 4
SKCa4	intermediate conductance K channel
intermediate-conductance Ca-activated K channel	potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
potassium intermediate/small conductance c

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07172	KCNN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20432	Kcnn4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26941	Kcnn4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcnn4	NCBI	NCBI:3783

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