2. Gene
  3. MRPL32 - mitochondrial ribosomal protein L32 Gene

MRPL32 - mitochondrial ribosomal protein L32 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as L32mt; HSPC283; MRP-L32; bMRP-59b

Gene ID: 64983 | Gene type: protein coding

About MRPL32

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:42,932,376-42,937,857 (from NCBI)

This gene has 4 transcripts (splice variants) and 222 orthologues. Ubiquitous expression in adrenal (RPKM 30.6), kidney (RPKM 28.9) and 25 other tissues.

Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]

MRPL32 Products(1)

mRNA Protein Name
NM_031903.3 NP_114109.1 39S ribosomal protein L32, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
part of mitochondrial large ribosomal subunit IDA
IDA: Inferred from direct assay
25278503 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
28892042 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRPL32 Protein Structure

Ribosomal_L32p

Ribosomal_L32p: Ribosomal L32p protein family (79 - 129)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

39S ribosomal protein L32, mitochondrial

mitochondrial large ribosomal subunit protein bL32m

MRPL32 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MRPL32 Q9BYC8 PRDM14 Homo sapiens Q9GZV8
Y2H Prey Pooling
32296183
Intra
MRPL32 Q9BYC8 PRDM14 Homo sapiens Q9GZV8
Y2H Array
32296183
Intra
MRPL32 Q9BYC8 PRDM14 Homo sapiens Q9GZV8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08670 MRPL32 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MRPL32 VGNC VGNC:102641
Bos taurus MRPL32 VGNC VGNC:31631
Canis familiaris MRPL32 VGNC VGNC:43391
Rattus norvegicus MRPL32 RGD RGD:1310541
Mus musculus MRPL32 MGD MGI:2137226
Macaca mulatta MRPL32 VGNC VGNC:108422