Svep1 - sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Gene

Mus musculus

Also known as Polydom; 1110021D17Rik; 4833413O10Rik; D430029O09Rik

Gene ID: 64817 | Gene type: protein coding

About Svep1

Summary

Enables chromatin binding activity. Acts upstream of or within several processes, including Tie signaling pathway; lymph circulation; and lymph vessel morphogenesis. Located in extracellular space. Is expressed in several structures, including alimentary system; forelimb bud; genitourinary system; spleen; and turbinate bone primordium. Orthologous to human SVEP1 (sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Svep1 Products(1)

mRNA	Protein	Name
NM_022814.2	NP_073725.2	sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	15522233	MGI
enables integrin binding	IMP IMP: Inferred from mutant phenotype	28179430	MGI
enables integrin binding involved in cell-matrix adhesion	IDA IDA: Inferred from direct assay	22654117	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	28179430	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Tie signaling pathway	IMP IMP: Inferred from mutant phenotype	28179430	MGI
acts upstream of or within epidermis development	IMP IMP: Inferred from mutant phenotype	27892606	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	28179430	MGI
acts upstream of or within lymph circulation	IMP IMP: Inferred from mutant phenotype	28179430	MGI
acts upstream of or within lymph vessel development	IMP IMP: Inferred from mutant phenotype	28179432	MGI
acts upstream of or within lymph vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	28179430	MGI
involved in positive regulation of platelet activation	IMP IMP: Inferred from mutant phenotype	36792666	MGI
acts upstream of or within tight junction organization	IMP IMP: Inferred from mutant phenotype	28179432	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	22654117	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	28179430	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

polydomain protein (Polydom)

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14058	SVEP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21775	Svep1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28292	Svep1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Svep1	NCBI	NCBI:79987

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