2. Gene
  3. Suv39h2 - suppressor of variegation 3-9 2 Gene

Suv39h2 - suppressor of variegation 3-9 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as KMT1B; D2Ertd544e; 4930507K23Rik; D030054H19Rik

Gene ID: 64707 | Gene type: protein coding

About Suv39h2

Summary

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; chromatin binding activity; and histone-lysine N-methyltransferase activity. Involved in histone H3-K9 methylation; negative regulation of circadian rhythm; and negative regulation of transcription, DNA-templated. Acts upstream of or within histone H3-K9 methylation and male meiotic nuclear division. Located in heterochromatin and nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and limb. Orthologous to human SUV39H2 (SUV39H2 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Suv39h2 Products(1)

mRNA Protein Name
NM_022724.4 NP_073561.2 histone-lysine N-methyltransferase SUV39H2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21402781 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
11094092 MGI
enables histone H3 methyltransferase activity IDA
IDA: Inferred from direct assay
10949293 MGI
enables histone H3K9 methyltransferase activity IGI
IGI: Inferred from genetic interaction
15788566 MGI
enables histone H3K9me2 methyltransferase activity IGI
IGI: Inferred from genetic interaction
23451023 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
24413057 MGI
enables protein methyltransferase activity IDA
IDA: Inferred from direct assay
11094092 MGI
enables transcription cis-regulatory region binding IDA
IDA: Inferred from direct assay
24413057 MGI
Biological Process GO Annotation Evidence Reference Source
involved in circadian rhythm IMP
IMP: Inferred from mutant phenotype
24413057 MGI
involved in male meiotic nuclear division IEP
IEP: Inferred from expression pattern
11094092 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
24413057 MGI
involved in negative regulation of gene expression, epigenetic IMP
IMP: Inferred from mutant phenotype
24413057 MGI
Cellular Component GO Annotation Evidence Reference Source
located in heterochromatin IDA
IDA: Inferred from direct assay
11094092 MGI
located in nucleus IDA
IDA: Inferred from direct assay
21402781 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase SUV39H2

H3-K9-HMTase 2

Suv39h histone methyltransferase

histone H3-K9 methyltransferase 2

su(var)3-9 homolog 2

suppressor of variegation 3-9 homolog 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122181B OTS186935 hydrochloride Inhibitor 99.58% Unkown
HY-122181 OTS186935 Inhibitor 98.55% Unkown
HY-13807 UNC0646 Inhibitor 99.38% Unkown
HY-122182 OTS193320 98.64% Unkown
HY-148817 WDR5-0102 Inhibitor 97.02% Unkown
HY-122181A OTS186935 trihydrochloride Inhibitor / Unkown
HY-RS14052 SUV39H2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18319 Suv39h2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24797 Suv39h2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Suv39h2 NCBI NCBI:79723