Zic1 - Zic family member 1 Gene

About Zic1

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including central nervous system development; positive regulation of protein import into nucleus; and regulation of smoothened signaling pathway. Predicted to act upstream of or within adult walking behavior. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Dandy-Walker syndrome and craniosynostosis. Orthologous to human ZIC1 (Zic family member 1). [provided by Alliance of Genome Resources, Apr 2022]