2. Gene
  3. Ireb2 - iron responsive element binding protein 2 Gene

Ireb2 - iron responsive element binding protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Irp2; D9Ertd85e

Gene ID: 64602 | Gene type: protein coding

About Ireb2

Summary

Enables iron-responsive element binding activity. Acts upstream of or within several processes, including intestinal absorption; osteoclast differentiation; and protoporphyrinogen IX biosynthetic process. Located in cytosol. Is expressed in several structures, including nervous system and yolk sac. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ireb2 Products(1)

mRNA Protein Name
NM_022655.3 NP_073146.2 iron-responsive element-binding protein 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables iron-responsive element binding IDA
IDA: Inferred from direct assay
8262972 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within erythrocyte homeostasis IMP
IMP: Inferred from mutant phenotype
15831703 MGI
acts upstream of or within intestinal absorption IGI
IGI: Inferred from genetic interaction
18177727 MGI
acts upstream of or within intracellular iron ion homeostasis IDA
IDA: Inferred from direct assay
11175792 MGI
acts upstream of or within intracellular iron ion homeostasis IGI
IGI: Inferred from genetic interaction
14726953 MGI
acts upstream of or within intracellular iron ion homeostasis IMP
IMP: Inferred from mutant phenotype
14726953 MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis IGI
IGI: Inferred from genetic interaction
21907140 MGI
involved in osteoclast differentiation IEP
IEP: Inferred from expression pattern
19252502 MGI
acts upstream of or within post-embryonic development IGI
IGI: Inferred from genetic interaction
18177727 MGI
acts upstream of or within protoporphyrinogen IX biosynthetic process IMP
IMP: Inferred from mutant phenotype
15831703 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
18177727 MGI
acts upstream of or within regulation of translation IMP
IMP: Inferred from mutant phenotype
14726953 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8262972 MGI
located in cytosol IDA
IDA: Inferred from direct assay
16144863 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

iron-responsive element-binding protein 2

IRE-BP 2

iron regulatory protein 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06901 IREB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20966 Ireb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27483 Ireb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ireb2 NCBI NCBI:3658