2. Gene
  3. Gpx3 - glutathione peroxidase 3 Gene

Gpx3 - glutathione peroxidase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Gpxp; GPx-3; GPx-P; GSHPx-3; GSHPx-P

Gene ID: 64317 | Gene type: protein coding

About Gpx3

Summary

The protein encoded by this gene belongs to the Glutathione Peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted and is predominantly expressed in rat kidney, which appears to be the major source of the enzyme in plasma. Dysregulation of this isozyme has been associated with obesity-related metabolic complications. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Aug 2016]

Gpx3 Products(1)

mRNA Protein Name
NM_022525.4 NP_071970.2 glutathione peroxidase 3 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables mercury ion binding IDA
IDA: Inferred from direct assay
29771257 RGD
enables selenium binding IDA
IDA: Inferred from direct assay
10746307 RGD
Biological Process GO Annotation Evidence Reference Source
involved in response to corticosterone IEP
IEP: Inferred from expression pattern
15755911 RGD
involved in response to molecule of fungal origin IEP
IEP: Inferred from expression pattern
18279679 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
14673789 RGD
involved in response to selenium ion IEP
IEP: Inferred from expression pattern
19398061 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18598687 RGD
Cellular Component GO Annotation Evidence Reference Source
located in extracellular space IDA
IDA: Inferred from direct assay
14673789 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutathione peroxidase 3

plasma glutathione peroxidase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05766 GPX3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18479 Gpx3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24960 Gpx3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gpx3 NCBI NCBI:2878