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  3. Tdo2 - tryptophan 2,3-dioxygenase Gene

Tdo2 - tryptophan 2,3-dioxygenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as TO; Tdo

Gene ID: 64206 | Gene type: protein coding

About Tdo2

Summary

Enables several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Involved in response to nitroglycerin and tryptophan catabolic process to acetyl-CoA. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Tdo2 Products(1)

mRNA Protein Name
NM_022403.2 NP_071798.1 tryptophan 2,3-dioxygenase
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables amino acid binding IDA
IDA: Inferred from direct assay
3899109 RGD
enables heme binding IDA
IDA: Inferred from direct assay
3400092 RGD
enables oxygen binding IDA
IDA: Inferred from direct assay
10719243 RGD
enables tryptophan 2,3-dioxygenase activity IDA
IDA: Inferred from direct assay
3400092 RGD
Biological Process GO Annotation Evidence Reference Source
involved in response to nitroglycerin IEP
IEP: Inferred from expression pattern
28659861 RGD
involved in tryptophan catabolic process to acetyl-CoA IDA
IDA: Inferred from direct assay
7236232 RGD
involved in tryptophan metabolic process IDA
IDA: Inferred from direct assay
3400092 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tryptophan 2,3-dioxygenase

TRPO

tryptamin 2,3-dioxygenase

tryptophan 2,3-dioxygenase A

tryptophan oxygenase

tryptophan pyrrolase

tryptophan-23-dioxygenase

tryptophanase

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-161348 AT-0174 Inhibitor / Unkown
HY-114319 β-Cembrenediol / Unkown
HY-161996 IDO1-IN-25 Inhibitor / Unkown
HY-RS14331 TDO2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-170322 Human TDO2-IN-1 / Unkown
HY-RS18976 Tdo2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25465 Tdo2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tdo2 NCBI NCBI:6999