Trpv6 - transient receptor potential cation channel, subfamily V, member 6 Gene

Mus musculus

Also known as CAT; Cac; CaT1; Ecac2; Otrpc3

Gene ID: 64177 | Gene type: protein coding

About Trpv6

Summary

Enables Calcium Channel activity and identical protein binding activity. Involved in calcium ion import across plasma membrane and response to calcium ion. Acts upstream of or within calcium ion transport and parathyroid hormone secretion. Part of Calcium Channel complex. Is expressed in alimentary system; central nervous system; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in hyperparathyroidism. Orthologous to human TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Apr 2022]

Trpv6 Products(1)

mRNA	Protein	Name
NM_022413.4	NP_071858.3	transient receptor potential cation channel subfamily V member 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	12077127	MGI
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	12574114	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	12574114	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12574114	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	17129178	MGI
involved in calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	22878123	MGI
involved in calcium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	22878123	MGI
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	12574114	MGI
acts upstream of or within calcium ion transport	IDA IDA: Inferred from direct assay	12077127	MGI
acts upstream of or within parathyroid hormone secretion	IMP IMP: Inferred from mutant phenotype	17129178	MGI
involved in response to calcium ion	IDA IDA: Inferred from direct assay	22878123	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of calcium channel complex	IDA IDA: Inferred from direct assay	12574114	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily V member 6

calcium transport protein 1	epithelial calcium channel 2
osmosensitive transient receptor potential channel 3

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1651A	SOR-C13 TFA	Antagonist	99.18%	Phase 1
HY-P1651	SOR-C13	Antagonist	99.10%	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1651B	SOR-C13 acetate	Antagonist	98.56%	Unkown
HY-P10762	Ricorfotide vedotin	Ligand	/	Unkown
HY-P4856	pTH-Related Protein (1-40) (human, mouse, rat)	Activator	/	Unkown
HY-RS15126	TRPV6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-157574	TRPV6-IN-1	Inhibitor	/	Unkown
HY-RS16943	Trpv6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23386	Trpv6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpv6	NCBI	NCBI:55503

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