Sv2a - synaptic vesicle glycoprotein 2 a Gene

Mus musculus

Also known as mKIAA0736

Gene ID: 64051 | Gene type: protein coding

About Sv2a

Summary

Enables protein kinase binding activity. Involved in synaptic vesicle priming. Acts upstream of or within cellular calcium ion homeostasis. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and synaptic vesicle. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human SV2A (synaptic vesicle glycoprotein 2A). [provided by Alliance of Genome Resources, Apr 2022]

Sv2a Products(1)

mRNA	Protein	Name
NM_022030.3	NP_071313.1	synaptic vesicle glycoprotein 2A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein kinase binding	IPI IPI: Inferred from physical interaction	21307259	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	10624962	MGI
involved in synaptic vesicle priming	IDA IDA: Inferred from direct assay	19176798	MGI
involved in synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	19176798	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	19176798	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	19176798	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	12074840	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19176798	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19176798	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	15713258	MGI
is active in neuron projection	IDA IDA: Inferred from direct assay	21664258	MGI
is active in presynaptic active zone	IDA IDA: Inferred from direct assay	21664258	MGI
located in presynaptic active zone	IDA IDA: Inferred from direct assay	24035762	MGI
located in synaptic vesicle	IDA IDA: Inferred from direct assay	10624962	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptic vesicle glycoprotein 2A

calcium regulator SV2A	synaptic vesicle protein 2
synaptic vesicle protein 2A

Sv2a Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87089	SV2A Antibody (YA6782)	IHC-F, IHC-P, WB	Mouse, Rat

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0106	Levetiracetam	Inhibitor	99.98%	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-119810	Seletracetam	Modulator	99.88%	Phase 3
HY-119810B	Seletracetam lithium bromide	Modulator	/	Phase 3
HY-136873	UCB-J		99.62%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-119810A	Seletracetam lithium		/	Phase 3

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-157999	SDI-118	Modulator	98.86%	Unkown
HY-167830	SDM-8		/	Unkown
HY-B0106S	Levetiracetam-d6	Inhibitor	/	Unkown
HY-RS14054	SV2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-B0106S1	Levetiracetam-d3	Inhibitor	/	Unkown
HY-RS16880	Sv2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23322	Sv2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sv2a	NCBI	NCBI:9900

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