Ccnd2 - cyclin D2 Gene

Rattus norvegicus

Gene ID: 64033 | Gene type: protein coding

About Ccnd2

Summary

Enables protein kinase binding activity. Involved in several processes, including cellular response to Insulin stimulus; response to estradiol; and response to testosterone. Predicted to be located in chromatin; cytosol; and nucleus. Predicted to be part of cyclin D2-CDK4 complex. Predicted to be active in cytoplasm and nucleus. Used to study transitional cell carcinoma. Biomarker of colon cancer; glaucoma; impotence; and nephritis. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; invasive lobular carcinoma; prostate cancer; and transitional cell carcinoma. Orthologous to human CCND2 (cyclin D2). [provided by Alliance of Genome Resources, Apr 2022]

Ccnd2 Products(1)

mRNA	Protein	Name
NM_022267.2	NP_071603.2	G1/S-specific cyclin-D2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein kinase binding	IPI IPI: Inferred from physical interaction	15809057	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G1/S transition of mitotic cell cycle	IEP IEP: Inferred from expression pattern	7926809	RGD
involved in G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	12130558	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	27302109	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	15613482	RGD
involved in cellular response to growth hormone stimulus	IEP IEP: Inferred from expression pattern	12586844	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	16210359	RGD
involved in cellular response to testosterone stimulus	IEP IEP: Inferred from expression pattern	23028064	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	15809057	RGD
involved in negative regulation of cardiac muscle cell differentiation	IDA IDA: Inferred from direct assay	27302109	RGD
involved in ovarian follicle development	IEP IEP: Inferred from expression pattern	17971845	RGD
involved in positive regulation of cardiac muscle cell proliferation	IDA IDA: Inferred from direct assay	27302109	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	12130558	RGD
involved in positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	7811475	RGD
involved in regulation of neuron differentiation	IEP IEP: Inferred from expression pattern	8028782	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	9658398	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	12437973	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	9658398	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	12480138	RGD
involved in response to follicle-stimulating hormone	IEP IEP: Inferred from expression pattern	9658398	RGD
involved in response to human chorionic gonadotropin	IEP IEP: Inferred from expression pattern	9658398	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	7811475	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	14691013	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	15659706	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	15659706	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

G1/S-specific cyclin-D2

vin-1 proto-oncogene

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124129	10074-A4	Inhibitor	98.22%	Unkown
HY-RS02124	CCND2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17697	Ccnd2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24159	Ccnd2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ccnd2	NCBI	NCBI:894

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