Dusp10 - dual specificity phosphatase 10 Gene

Mus musculus

Also known as MKP5; MKP-5; 2610306G15Rik

Gene ID: 63953 | Gene type: protein coding

About Dusp10

Summary

Enables MAP kinase Phosphatase activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of epithelial cell migration; and negative regulation of epithelium regeneration. Acts upstream of or within several processes, including negative regulation of protein kinase activity; negative regulation of respiratory burst involved in inflammatory response; and oligodendrocyte differentiation. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human DUSP10 (dual specificity Phosphatase 10). [provided by Alliance of Genome Resources, Apr 2022]

Dusp10 Products(1)

mRNA	Protein	Name
NM_022019.6	NP_071302.2	dual specificity protein phosphatase 10

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables MAP kinase phosphatase activity	IDA IDA: Inferred from direct assay	25772234	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	25772234	MGI
acts upstream of or within negative regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	15306813	MGI
acts upstream of or within negative regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	15306813	MGI
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	25772234	MGI
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	25772234	MGI
involved in negative regulation of epithelium regeneration	IDA IDA: Inferred from direct assay	25772234	MGI
acts upstream of or within negative regulation of protein kinase activity by regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	23977283	MGI
acts upstream of or within negative regulation of respiratory burst involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	19696743	MGI
acts upstream of or within negative regulation of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	19696743	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	19139271	MGI
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	25772234	MGI
acts upstream of or within regulation of adaptive immune response	IMP IMP: Inferred from mutant phenotype	15306813	MGI
acts upstream of or within regulation of brown fat cell differentiation	IDA IDA: Inferred from direct assay	23874687	MGI
acts upstream of or within regulation of innate immune response	IMP IMP: Inferred from mutant phenotype	15306813	MGI
acts upstream of or within response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	19696743	MGI
acts upstream of stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	19696743	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dual specificity protein phosphatase 10

MAP kinase phosphatase 5

mitogen-activated protein kinase phosphatase 5

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04051	DUSP10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21119	Dusp10 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27638	Dusp10 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dusp10	NCBI	NCBI:11221

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