2. Gene
  3. Per2 - period circadian regulator 2 Gene

Per2 - period circadian regulator 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as rPER2

Gene ID: 63840 | Gene type: protein coding

About Per2

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders. [provided by RefSeq, Jan 2014]

Per2 Products(1)

mRNA Protein Name
NM_031678.2 NP_113866.1 period circadian protein homolog 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
9765215 RGD
Biological Process GO Annotation Evidence Reference Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
9765215 RGD
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
12397359 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12397359 RGD
involved in neural retina development IEP
IEP: Inferred from expression pattern
20589906 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

period circadian protein homolog 2

circadian clock protein PERIOD 2

period circadian clock 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-119506 KL044 99.05% Unkown
HY-RS10332 PER2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20323 Per2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26831 Per2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Per2 NCBI NCBI:8864