Mark2 - microtubule affinity regulating kinase 2 Gene

Rattus norvegicus

Gene ID: 60328 | Gene type: protein coding

About Mark2

Summary

Enables protein N-terminus binding activity; protein kinase activity; and Tau Protein binding activity. Involved in several processes, including establishment or maintenance of cell polarity regulating cell shape; generation of neurons; and protein phosphorylation. Located in membrane. Orthologous to human MARK2 (microtubule affinity regulating kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mark2 Products(2)

mRNA	Protein	Name
NM_001398633.1	NP_001385562.1	serine/threonine-protein kinase MARK2 isoform 2
NM_021699.3	NP_067731.1	serine/threonine-protein kinase MARK2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14741102	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14741102	RGD
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	9108484	RGD
enables tau protein binding	IPI IPI: Inferred from physical interaction	24251416	RGD
enables tau-protein kinase activity	IDA IDA: Inferred from direct assay	14517247	RGD
enables tau-protein kinase activity	IMP IMP: Inferred from mutant phenotype	24251416	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon development	IMP IMP: Inferred from mutant phenotype	16717194	RGD
involved in establishment or maintenance of cell polarity regulating cell shape	IMP IMP: Inferred from mutant phenotype	16717194	RGD
involved in neuron migration	IDA IDA: Inferred from direct assay	14741102	RGD
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	10542369	RGD
involved in peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	16717194	RGD
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	14517247	RGD
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	9108484	RGD
involved in regulation of cytoskeleton organization	IDA IDA: Inferred from direct assay	14517247	RGD
involved in regulation of microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	10542369	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	22807451	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	22807451	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	22807451	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	22807451	RGD
located in membrane	IDA IDA: Inferred from direct assay	14741102	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

serine/threonine-protein kinase MARK2

ELKL motif kinase 1	EMK-1
EMK1	MAP/microtubule affinity-regulating kinase 2
serine/threonine kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120877	MRT199665		99.74%	Unkown
HY-139604	PCC0208017		99.56%	Unkown
HY-148062	RSS0680		98.03%	Unkown
HY-120877A	(R)-MRT199665		98.70%	Unkown
HY-RS08150	MARK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17609	Mark2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24069	Mark2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mark2	NCBI	NCBI:2011

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