Phlpp1 - PH domain and leucine rich repeat protein phosphatase 1 Gene

Rattus norvegicus

Also known as Scop; Phlpp; Plekhe1

Gene ID: 59265 | Gene type: protein coding

About Phlpp1

Summary

Enables protein serine/threonine Phosphatase activity. Involved in several processes, including hippocampus development; protein dephosphorylation; and regulation of intracellular signal transduction. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein Phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]

Phlpp1 Products(1)

mRNA	Protein	Name
NM_021657.2	NP_067689.2	PH domain leucine-rich repeat protein phosphatase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein serine/threonine phosphatase activity	IDA IDA: Inferred from direct assay	20089132	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	10570941	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	20819118	RGD
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	20819118	RGD
involved in negative regulation of protein kinase C signaling	IMP IMP: Inferred from mutant phenotype	20819118	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	20819118	RGD
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	20089132	RGD
involved in protein dephosphorylation	IMP IMP: Inferred from mutant phenotype	20819118	RGD
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	20819118	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20819118	RGD
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	20819118	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	20819118	RGD
located in nucleoplasm	IDA IDA: Inferred from direct assay	20819118	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	20819118	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

PH domain leucine-rich repeat protein phosphatase 1

Circadian Oscillatory Protein (SCOP)	PH domain leucine-rich repeat-containing protein phosphatase 1
PH domain-containing family E member 1	SCN circadian oscillatory protein
pleckstrin homology domain containing, family E (with leucine rich repeats) me

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19820A	NSC45586 sodium		≥98.0%	Unkown
HY-19820	NSC45586		/	Unkown
HY-RS10447	PHLPP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18428	Phlpp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24909	Phlpp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Phlpp1	NCBI	NCBI:23239

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