Ago2 - argonaute RISC catalytic component 2 Gene

Rattus norvegicus

Also known as Eif2c2; eIF2C 2

Gene ID: 59117 | Gene type: protein coding

About Ago2

Summary

Predicted to enable several functions, including endoribonuclease activity, producing 5'-phosphomonoesters; nucleic acid binding activity; and protein C-terminus binding activity. Involved in negative regulation of amyloid precursor protein biosynthetic process. Located in mitochondrion. Orthologous to human AGO2 (argonaute RISC catalytic component 2). [provided by Alliance of Genome Resources, Apr 2022]

Ago2 Products(1)

mRNA	Protein	Name
NM_001408918.1	NP_001395847.1	protein argonaute-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp70 protein binding	IDA IDA: Inferred from direct assay	11553639	RGD
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	11553639	RGD
enables RISC complex binding	IDA IDA: Inferred from direct assay	30404558	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	24882364	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to calcium ion	IEP IEP: Inferred from expression pattern	28404816	RGD
involved in negative regulation of amyloid precursor protein biosynthetic process	IMP IMP: Inferred from mutant phenotype	20395292	RGD
involved in positive regulation of post-transcriptional gene silencing by RNA	IMP IMP: Inferred from mutant phenotype	15147961	RGD
involved in regulation of mRNA stability	IMP IMP: Inferred from mutant phenotype	26846850	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	26944283	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	21969601	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	23927484	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	27029769	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11553639	RGD
located in P granule	IDA IDA: Inferred from direct assay	27029769	RGD
part of RISC complex	IDA IDA: Inferred from direct assay	30404558	RGD
located in chromatoid body	IDA IDA: Inferred from direct assay	27029769	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	27029769	RGD
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	30404558	RGD
located in cytosol	IDA IDA: Inferred from direct assay	27029769	RGD
located in dendrite	IDA IDA: Inferred from direct assay	28404816	RGD
located in membrane	IDA IDA: Inferred from direct assay	11553639	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	22518031	RGD
located in pi-body	IDA IDA: Inferred from direct assay	27029769	RGD
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	23041308	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein argonaute-2

argonaute 2, RISC catalytic component	argonaute2
eukaryotic translation initiation factor 2C 2	golgi ER protein 95 kDa

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119024	BCI-137		99.55%	Unkown
HY-RS00453	AGO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17683	Ago2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24144	Ago2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ago2	NCBI	NCBI:27161
Mus musculus	Ago2	NCBI	NCBI:239528

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