Asl - argininosuccinate lyase Gene

Rattus norvegicus

Gene ID: 59085 | Gene type: protein coding

About Asl

Summary

Enables argininosuccinate lyase activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to organic cyclic compound; and response to peptide hormone. Located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). [provided by Alliance of Genome Resources, Apr 2022]

Asl Products(1)

mRNA	Protein	Name
NM_021577.3	NP_067588.2	argininosuccinate lyase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables argininosuccinate lyase activity	IDA IDA: Inferred from direct assay	4062872	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in argininosuccinate metabolic process	IDA IDA: Inferred from direct assay	4062872	RGD
involved in cellular response to ammonium ion	IEP IEP: Inferred from expression pattern	10353334	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	11097477	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	8923475	RGD
involved in cellular response to glucagon stimulus	IEP IEP: Inferred from expression pattern	8387274	RGD
involved in cellular response to glucocorticoid stimulus	IEP IEP: Inferred from expression pattern	11097477	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	11097477	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	11072090	RGD
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	11072090	RGD
involved in diaphragm development	IEP IEP: Inferred from expression pattern	9618389	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	10473900	RGD
involved in liver development	IDA IDA: Inferred from direct assay	9535537	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	10473900	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	9544996	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	16168957	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	9688877	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	8576237	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	2547341	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	8387274	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	9688877	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	20452409	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	9535537	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	11686772	RGD
involved in urea cycle	IDA IDA: Inferred from direct assay	4062872	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body fiber	IDA IDA: Inferred from direct assay	12445581	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	8867809	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12445581	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	17900569	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15199240	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

argininosuccinate lyase

ASAL	arginosuccinase

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0451A	Dopamine hydrochloride	Inhibitor	99.61%	Unkown
HY-B0451	Dopamine	Inhibitor	98.27%	Unkown

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113284	Succinyladenosine		99.43%	Unkown
HY-B0451AS4	Dopamine-d3 hydrochloride		99.88%	Unkown
HY-B0451AS7	Dopamine-d5 hydrochloride	Inhibitor	99.6%	Unkown
HY-B0451AS1	Dopamine-13C6 hydrochloride		98.71%	Unkown
HY-B0451AS5	Dopamine-13C hydrochloride		99.74%	Unkown
HY-B0451AS2	Dopamine-d2 hydrochloride		/	Unkown
HY-B0451AS3	Dopamine-d2-1 hydrochloride		/	Unkown
HY-RS00418	ADSL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01095	ASL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W752476	Succinyladenosine-13C4		/	Unkown
HY-158987	Adenosine phosphonobutyric, 2'(3'), 5'-diposphate		/	Unkown
HY-B0451AS6	Dopamine-13C,15N hydrochloride		99.02%	Unkown
HY-RS16982	Asl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18123	Adsl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23425	Asl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W416440	Esmolol acid hydrochloride	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Asl	NCBI	NCBI:435
Mus musculus	Asl	NCBI	NCBI:109900

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