2. Gene
  3. Grk6 - G protein-coupled receptor kinase 6 Gene

Grk6 - G protein-coupled receptor kinase 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Gprk6

Gene ID: 59076 | Gene type: protein coding

About Grk6

Summary

Enables G protein-coupled receptor kinase activity. Involved in several processes, including cellular response to lipopolysaccharide; desensitization of G protein-coupled receptor signaling pathway; and negative regulation of anion channel activity. Located in cytosol and plasma membrane. Biomarker of Parkinson's disease. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6). [provided by Alliance of Genome Resources, Apr 2022]

Grk6 Products(3)

mRNA Protein Name
NM_001112712.2 NP_001106183.1 G protein-coupled receptor kinase 6 isoform c
NM_001112713.1 NP_001106184.1 G protein-coupled receptor kinase 6 isoform b
NM_031657.4 NP_113845.2 G protein-coupled receptor kinase 6 isoform a
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled receptor kinase activity IDA
IDA: Inferred from direct assay
12810562 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
23359120 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12810562 RGD
involved in desensitization of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17908240 RGD
involved in negative regulation of anion channel activity IMP
IMP: Inferred from mutant phenotype
17170521 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12810562 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

G protein-coupled receptor kinase 6

g protein-coupled receptor kinase GRK6

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-128231 GRK6-IN-4 Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-142812 GRK6-IN-1 99.61% Unkown
HY-142817 GRK6-IN-2 98.98% Unkown
HY-128311 GRK6-IN-3 Inhibitor / Unkown
HY-150021 GRK5-IN-3 Inhibitor / Unkown
HY-RS05817 GRK6 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-159996 GRL093-22 Inhibitor / Unkown
HY-169678 GRK6-IN-5 Inhibitor / Unkown
HY-174256 GRL-098-22 Inhibitor / Unkown
HY-RS17369 Grk6 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23823 Grk6 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grk6 NCBI NCBI:2870