Slc4a8 - solute carrier family 4 (anion exchanger), member 8 Gene

Mus musculus

Also known as NDCBE; kNBC-3; C230026C11

Gene ID: 59033 | Gene type: protein coding

About Slc4a8

Summary

Predicted to enable chloride transmembrane transporter activity and sodium:bicarbonate symporter activity. Acts upstream of or within positive regulation of synaptic vesicle exocytosis and regulation of intracellular pH. Located in several cellular components, including glutamatergic synapse; neuronal cell body membrane; and presynaptic membrane. Is expressed in several structures, including adrenal gland; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human SLC4A8 (solute carrier family 4 member 8). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a8 Products(2)

mRNA	Protein	Name
NM_001347102.1	NP_001334031.1	electroneutral sodium bicarbonate exchanger 1 isoform 2
NM_021530.2	NP_067505.2	electroneutral sodium bicarbonate exchanger 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables sodium,bicarbonate:chloride antiporter activity	IDA IDA: Inferred from direct assay	20389022	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	23677982	MGI
acts upstream of or within modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	21593314	MGI
acts upstream of or within positive regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	21593314	MGI
acts upstream of or within regulation of intracellular pH	IMP IMP: Inferred from mutant phenotype	21593314	MGI
involved in regulation of synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	21593314	MGI
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	21593314	MGI
involved in regulation of synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	21593314	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	30355950	MGI
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	21593314	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21593314	MGI
located in glutamatergic synapse	IDA IDA: Inferred from direct assay	21593314	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	21593314	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21593314	MGI
located in membrane	IDA IDA: Inferred from direct assay	18359573	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	18359573	MGI
located in neuronal cell body membrane	IDA IDA: Inferred from direct assay	18359573	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	18359573	MGI
located in presynapse	IDA IDA: Inferred from direct assay	21593314	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	21593314	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	21593314	MGI
is active in presynaptic membrane	IEP IEP: Inferred from expression pattern	21593314	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

electroneutral sodium bicarbonate exchanger 1

electroneutral Na+-driven Cl-HCO3 exchanger	k-NBC3
solute carrier family 4 member 8

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13273	SLC4A8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21937	Slc4a8 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc4a8	NCBI	NCBI:9498

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