2. Gene
  3. Ngly1 - N-glycanase 1 Gene

Ngly1 - N-glycanase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Png1; PNGase; 1110002C09Rik

Gene ID: 59007 | Gene type: protein coding

About Ngly1

Summary

Predicted to enable peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity. Involved in glycoprotein catabolic process. Located in cytoplasm. Is expressed in axial musculature; nervous system; thymus primordium; and vibrissa. Human ortholog(s) of this gene implicated in NGLY1-deficiency. Orthologous to human NGLY1 (N-glycanase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ngly1 Products(3)

mRNA Protein Name
NM_001362432.1 NP_001349361.1 peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform 2
NM_001362433.1 NP_001349362.1 peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform 3
NM_021504.3 NP_067479.2 peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15358861 MGI
Biological Process GO Annotation Evidence Reference Source
involved in glycoprotein catabolic process IDA
IDA: Inferred from direct assay
15358861 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15358861 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

peptide N-glycanase homolog

Ngly1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Ngly1 Q9JI78 Amfr Mus musculus Q9R049
Confocal
16709668
Cross
Ngly1 Q9JI78 RAD23A Homo sapiens P54725
NMR
22575648
Cross
Ngly1 Q9JI78 RAD23A Homo sapiens P54725
Affinity Chrom
22575648
Intra
Ngly1 Q9JI78 Vcp Mus musculus Q01853
Pull Down
16709668
Intra
Ngly1 Q9JI78 Vcp Mus musculus Q01853
ITC
17496150
Intra
Ngly1 Q9JI78 Vcp Mus musculus Q01853
X-Ray Diffraction
17496150
Intra
Ngly1 Q9JI78 Vcp Mus musculus Q01853
GMS
17496150
Intra
Ngly1 Q9JI78 Vcp Mus musculus Q01853
Pull Down
17496150
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-129225 WRR139 Inhibitor 99.71% Unkown
HY-N9446 H-Asn(glcnac-beta-D)-OH 98.65% Unkown
HY-P10135 RES-701-1 Antagonist / Unkown
HY-RS09279 NGLY1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-P2064 Lariatin A Inhibitor / Unkown
HY-RS19221 Ngly1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25710 Ngly1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ngly1 NCBI NCBI:55768