Txnrd1 - thioredoxin reductase 1 Gene

Rattus norvegicus

Also known as Tr

Gene ID: 58819 | Gene type: protein coding

About Txnrd1

Summary

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as Other substrates, and play a key role in redox homoeostasis. This gene encodes an ubiquitously expressed, cytosolic form of TrxR, which functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing, primarily at the 5' end, results in transcript variants encoding same or different isoforms. [provided by RefSeq, Jun 2017]

Txnrd1 Products(4)

mRNA	Protein	Name
NM_001351981.1	NP_001338910.1	thioredoxin reductase 1, cytoplasmic isoform 1
NM_001351983.1	NP_001338912.1	thioredoxin reductase 1, cytoplasmic isoform 1
NM_001351984.1	NP_001338913.1	thioredoxin reductase 1, cytoplasmic isoform 2
NM_031614.3	NP_113802.2	thioredoxin reductase 1, cytoplasmic isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD(P)H oxidase H2O2-forming activity	IDA IDA: Inferred from direct assay	16481328	RGD
enables NADPH peroxidase activity	IDA IDA: Inferred from direct assay	10849437	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	14607844	RGD
enables mercury ion binding	IDA IDA: Inferred from direct assay	20810785	RGD
enables selenate reductase activity	IDA IDA: Inferred from direct assay	20810785	RGD
enables thioredoxin-disulfide reductase (NADPH) activity	IDA IDA: Inferred from direct assay	10849437	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in NADPH oxidation	IDA IDA: Inferred from direct assay	19054767	RGD
involved in benzene-containing compound metabolic process	IDA IDA: Inferred from direct assay	20345183	RGD
involved in cellular response to copper ion	IEP IEP: Inferred from expression pattern	19781568	RGD
involved in cellular response to hyperoxia	IEP IEP: Inferred from expression pattern	21505996	RGD
involved in halogen metabolic process	IEP IEP: Inferred from expression pattern	21406454	RGD
involved in hydrogen peroxide catabolic process	IMP IMP: Inferred from mutant phenotype	10849437	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12574159	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	19833109	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	20493230	RGD
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	12435734	RGD
involved in response to selenium ion	IEP IEP: Inferred from expression pattern	15792362	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19768707	RGD
involved in selenocysteine metabolic process	IMP IMP: Inferred from mutant phenotype	10512699	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in neuronal cell body	IDA IDA: Inferred from direct assay	20620191	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

thioredoxin reductase 1, cytoplasmic

NADPH-dependent thioredoxin reductase	peroxidase TXNRD1
selenoprotein oxidoreductase	thioredoxin reductase TR1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125006	TRi-1	Activator	99.91%	Unkown
HY-147328	LCS3	Inducer	99.43%	Unkown
HY-RS15298	TXNRD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17152	Txnrd1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23602	Txnrd1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Txnrd1	NCBI	NCBI:7296

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