Apln - apelin Gene

Rattus norvegicus

Also known as Apel

Gene ID: 58812 | Gene type: protein coding

About Apln

Summary

Enables apelin receptor binding activity and identical protein binding activity. Involved in several processes, including apelin receptor signaling pathway; positive regulation of peptide hormone secretion; and regulation of blood circulation. Located in extracellular space and perinuclear region of cytoplasm. Used to study congestive heart failure. Biomarker of colitis; congestive heart failure; hypertension; and obesity. Orthologous to human APLN (apelin). [provided by Alliance of Genome Resources, Apr 2022]

Apln Products(1)

mRNA	Protein	Name
NM_031612.3	NP_113800.1	apelin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables apelin receptor binding	IDA IDA: Inferred from direct assay	11336787	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	15486224	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in apelin receptor signaling pathway	IDA IDA: Inferred from direct assay	11359874	RGD
involved in drinking behavior	IMP IMP: Inferred from mutant phenotype	10617103	RGD
involved in feeding behavior	IMP IMP: Inferred from mutant phenotype	14642423	RGD
involved in negative regulation of blood pressure	IDA IDA: Inferred from direct assay	15486224	RGD
involved in negative regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	10617103	RGD
involved in negative regulation of systemic arterial blood pressure	IDA IDA: Inferred from direct assay	12798955	RGD
involved in negative regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	17318790	RGD
involved in positive regulation of G protein-coupled receptor internalization	IDA IDA: Inferred from direct assay	11359874	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	14670994	RGD
involved in positive regulation of corticotropin secretion	IMP IMP: Inferred from mutant phenotype	16896162	RGD
involved in positive regulation of corticotropin-releasing hormone secretion	IMP IMP: Inferred from mutant phenotype	15541902	RGD
involved in positive regulation of heart contraction	IMP IMP: Inferred from mutant phenotype	26611206	RGD
involved in positive regulation of heart rate	IDA IDA: Inferred from direct assay	12798955	RGD
involved in positive regulation of heat generation	IMP IMP: Inferred from mutant phenotype	15541902	RGD
involved in positive regulation of phosphorylation	IMP IMP: Inferred from mutant phenotype	16556853	RGD
involved in regulation of body fluid levels	IMP IMP: Inferred from mutant phenotype	12787050	RGD
involved in regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	17055480	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	16674982	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15166125	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

apelin

APJ endogenous ligand

apelin, AGTRL1 ligand

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00822	APLN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18461	Apln Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24942	Apln Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apln	NCBI	NCBI:8862
Mus musculus	Apln	NCBI	NCBI:30878

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