PWP2 - PWP2 small subunit processome component Gene

Homo sapiens

Also known as UTP1; PWP2H; EHOC-17

Gene ID: 5822 | Gene type: protein coding

About PWP2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,107,399-44,131,181 (from NCBI)

This gene has 6 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in lymph node (RPKM 6.5), spleen (RPKM 6.3) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) and ribosomal small subunit assembly. Predicted to be located in nucleoplasm. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. [provided by Alliance of Genome Resources, Apr 2022]

PWP2 Products(1)

mRNA	Protein	Name
NM_005049.3	NP_005040.2	periodic tryptophan protein 2 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30021884	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PWP2 Protein Structure

WD40

Utp12

0
200
400
600
800
919 a.a.

Protein Preferred Names

Protein Names

periodic tryptophan protein 2 homolog

PWP2 periodic tryptophan protein homolog

Related Diseases

Diseases

Alias

Holoprosencephaly 1

Arhinencephaly	HPE1
Cyclopia	Holoprosencephaly, Familial Alobar
Hpe, Familial	Hpec
Demyer Sequence	Holoprosencephaly-1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11476	PWP2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PWP2	RGD	RGD:1582817
Mus musculus	PWP2	MGD	MGI:1341200

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