Bcl11b - B cell leukemia/lymphoma 11B Gene

Mus musculus

Also known as Rit1; Ctip2; BCL-11B; 9130430L19Rik; B630002E05Rik

Gene ID: 58208 | Gene type: protein coding

About Bcl11b

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; cell morphogenesis involved in differentiation; and regulation of keratinocyte proliferation. Located in neuron projection and nucleus. Is expressed in several structures, including alimentary system; central nervous system; craniocervical region bone; nose; and skin. Human ortholog(s) of this gene implicated in immunodeficiency 49. Orthologous to human BCL11B (BAF chromatin remodeling complex subunit BCL11B). [provided by Alliance of Genome Resources, Apr 2022]

Bcl11b Products(3)

mRNA	Protein	Name
NM_001079883.1	NP_001073352.1	B-cell lymphoma/leukemia 11B isoform a
NM_001286343.1	NP_001273272.1	B-cell lymphoma/leukemia 11B isoform c
NM_021399.2	NP_067374.2	B-cell lymphoma/leukemia 11B isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18595722	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16809611	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16809611	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	16809611	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	12717433	MGI
acts upstream of or within T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	16670294	MGI
acts upstream of or within T cell receptor V(D)J recombination	IMP IMP: Inferred from mutant phenotype	12717433	MGI
acts upstream of or within alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	12717433	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	12717433	MGI
acts upstream of or within axonogenesis	IMP IMP: Inferred from mutant phenotype	15664173	MGI
acts upstream of or within central nervous system neuron differentiation	IGI IGI: Inferred from genetic interaction	18215621	MGI
acts upstream of or within commitment of neuronal cell to specific neuron type in forebrain	IGI IGI: Inferred from genetic interaction	23144223	MGI
acts upstream of or within epithelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	19251658	MGI
acts upstream of or within keratinocyte development	IMP IMP: Inferred from mutant phenotype	19092943	MGI
acts upstream of or within negative regulation of T cell apoptotic process	IMP IMP: Inferred from mutant phenotype	12717433	MGI
acts upstream of or within negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	12565905	MGI
acts upstream of or within negative regulation of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	16670294	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	19251658	MGI
acts upstream of or within olfactory bulb axon guidance	IMP IMP: Inferred from mutant phenotype	21752992	MGI
acts upstream of or within positive T cell selection	IMP IMP: Inferred from mutant phenotype	17998389	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16809611	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16809611	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12717433	MGI
acts upstream of or within post-embryonic camera-type eye development	IMP IMP: Inferred from mutant phenotype	12717433	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	12717433	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21752992	MGI
acts upstream of or within regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	19092943	MGI
acts upstream of or within regulation of lipid metabolic process	IMP IMP: Inferred from mutant phenotype	19092943	MGI
acts upstream of or within regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	21752992	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	19092943	MGI
acts upstream of or within striatal medium spiny neuron differentiation	IMP IMP: Inferred from mutant phenotype	18199763	MGI
acts upstream of thymocyte apoptotic process	IMP IMP: Inferred from mutant phenotype	16670294	MGI
acts upstream of or within thymus development	IMP IMP: Inferred from mutant phenotype	12717433	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16809611	MGI
acts upstream of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	16809611	MGI
acts upstream of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	12717433	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of SWI/SNF complex	IDA IDA: Inferred from direct assay	23644491	MGI
located in intracellular anatomical structure	IDA IDA: Inferred from direct assay	18255031	MGI
located in neuron projection	IDA IDA: Inferred from direct assay	25100583	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12565905	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

B-cell lymphoma/leukemia 11B

B-cell CLL/lymphoma 11B	B-cell lymphoma/leukaemia 11B
COUP-TF-interacting protein 2	mRit1
radiation-induced tumor suppressor gene 1 protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01414	BCL11B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21827	Bcl11b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28344	Bcl11b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Bcl11b	NCBI	NCBI:64919

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