Rsad2 - radical S-adenosyl methionine domain containing 2 Gene

Mus musculus

Also known as Vig1; cig5; 2510004L01Rik

Gene ID: 58185 | Gene type: protein coding

About Rsad2

Summary

Predicted to enable 4 iron, 4 sulfur cluster binding activity and protein self-association. Involved in several processes, including negative regulation of viral genome replication; positive regulation of T-helper 2 cell cytokine production; and positive regulation of Toll-like Receptor signaling pathway. Located in endoplasmic reticulum and lipid droplet. Human ortholog(s) of this gene implicated in respiratory syncytial virus infectious disease. Orthologous to human RSAD2 (radical S-adenosyl methionine domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Rsad2 Products(1)

mRNA	Protein	Name
NM_021384.4	NP_067359.2	radical S-adenosyl methionine domain-containing protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21435586	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in CD4-positive, alpha-beta T cell activation	IMP IMP: Inferred from mutant phenotype	19047684	MGI
involved in CD4-positive, alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	19047684	MGI
involved in defense response to virus	IDA IDA: Inferred from direct assay	17686841	MGI
involved in negative regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	21880757	MGI
involved in positive regulation of T-helper 2 cell cytokine production	IMP IMP: Inferred from mutant phenotype	19047684	MGI
involved in positive regulation of toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	21435586	MGI
involved in positive regulation of toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	21435586	MGI
involved in response to virus	IMP IMP: Inferred from mutant phenotype	21880757	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23160199	MGI
located in lipid droplet	IDA IDA: Inferred from direct assay	19920176	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

radical S-adenosyl methionine domain-containing protein 2

VHSV-induced-like protein	viperin
viral hemorrhagic septicemia virus (VHSV)-induced gene 1	virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12297	RSAD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20486	Rsad2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26994	Rsad2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rsad2	NCBI	NCBI:91543

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