ZFYVE28 - zinc finger FYVE-type containing 28 Gene

Homo sapiens

Also known as LST2; LYST2; lst-2

Gene ID: 57732 | Gene type: protein coding

About ZFYVE28

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:2,269,597-2,418,645 (from NCBI)

This gene has 11 transcripts (splice variants), 215 orthologues and 13 paralogues. Ubiquitous expression in testis (RPKM 1.1), brain (RPKM 1.1) and 25 other tissues.

Summary

Enables phosphatidylinositol-3-phosphate binding activity. Involved in negative regulation of epidermal growth factor-activated receptor activity. Located in cytosol and early endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZFYVE28 Products(6)

mRNA	Protein	Name
NM_001172656.2	NP_001166127.1	lateral signaling target protein 2 homolog isoform 3
NM_001172657.2	NP_001166128.1	lateral signaling target protein 2 homolog isoform 4
NM_001172658.3	NP_001166129.1	lateral signaling target protein 2 homolog isoform 5
NM_001172659.2	NP_001166130.1	lateral signaling target protein 2 homolog isoform 1
NM_001172660.3	NP_001166131.1	lateral signaling target protein 2 homolog isoform 6
NM_020972.3	NP_066023.2	lateral signaling target protein 2 homolog isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables phosphatidylinositol-3-phosphate binding	IDA IDA: Inferred from direct assay	19460345	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19460345	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19460345	GOA
involved in negative regulation of epidermal growth factor-activated receptor activity	IMP IMP: Inferred from mutant phenotype	19460345	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	19460345	GOA
located in early endosome membrane	IDA IDA: Inferred from direct assay	19460345	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZFYVE28 Protein Structure

FYVE

0
200
400
600
800
887 a.a.

Protein Preferred Names

Protein Names

lateral signaling target protein 2 homolog

hLst2

Related Diseases

Diseases

Alias

Adiaspiromycosis

Anti-Basement Membrane Glomerulonephritis

Anti-Gbm Glomerulonephritis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16061	ZFYVE28 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZFYVE28	MGD	MGI:2684992
Macaca mulatta	ZFYVE28	VGNC	VGNC:107211
Bos taurus	ZFYVE28	VGNC	VGNC:37178
Canis familiaris	ZFYVE28	VGNC	VGNC:53255
Felis catus	ZFYVE28	VGNC	VGNC:107480
Rattus norvegicus	ZFYVE28	RGD	RGD:1310151

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