2. Gene
  3. PDP2 - pyruvate dehydrogenase phosphatase catalytic subunit 2 Gene

PDP2 - pyruvate dehydrogenase phosphatase catalytic subunit 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as PPM2B; PDPC 2; PPM2C2

Gene ID: 57546 | Gene type: protein coding

About PDP2

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:66,880,515-66,891,101 (from NCBI)

This gene has 9 transcripts (splice variants), 198 orthologues and 16 paralogues. Ubiquitous expression in thyroid (RPKM 4.8), kidney (RPKM 4.0) and 25 other tissues.

Summary

This gene is a mitochondrial protein that functions as a Phosphatase and is involved in the enzymatic resetting of the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2016]

PDP2 Products(8)

mRNA Protein Name
NM_001329928.2 NP_001316857.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329929.2 NP_001316858.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329930.2 NP_001316859.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329931.2 NP_001316860.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329932.2 NP_001316861.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329933.2 NP_001316862.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_001329934.2 NP_001316863.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor
NM_020786.4 NP_065837.1 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial precursor

PDP2 Protein Structure

PP2C

PP2C: Protein phosphatase 2C (227 - 442)

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  • 529 a.a.
Protein Preferred Names Protein Names

[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

protein phosphatase 2C, magnesium-dependent, catalytic subunit 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10286 PDP2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDP2 VGNC VGNC:75896
Bos taurus PDP2 VGNC VGNC:32714
Mus musculus PDP2 MGD MGI:1918878
Felis catus PDP2 VGNC VGNC:64094
Rattus norvegicus PDP2 RGD RGD:628812
Canis familiaris PDP2 VGNC VGNC:44389