Aldh1a3 - aldehyde dehydrogenase family 1, subfamily A3 Gene

Mus musculus

Also known as V1; ALDH6; RALDH3

Gene ID: 56847 | Gene type: protein coding

About Aldh1a3

Summary

Enables NAD+ binding activity; aldehyde dehydrogenase (NAD+) activity; and thyroid hormone binding activity. Involved in Harderian gland development; embryonic camera-type eye development; and nose development. Acts upstream of or within several processes, including nucleus accumbens development; righting reflex; and sensory organ development. Located in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in isolated microphthalmia 8. Orthologous to human ALDH1A3 (aldehyde dehydrogenase 1 family member A3). [provided by Alliance of Genome Resources, Apr 2022]

Aldh1a3 Products(1)

mRNA	Protein	Name
NM_053080.3	NP_444310.3	aldehyde dehydrogenase family 1 member A3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NAD+ binding	IDA IDA: Inferred from direct assay	16241904	MGI
enables aldehyde dehydrogenase (NAD+) activity	IDA IDA: Inferred from direct assay	11013254	MGI
enables aldehyde dehydrogenase [NAD(P)+] activity	IDA IDA: Inferred from direct assay	11044606	MGI
enables thyroid hormone binding	IPI IPI: Inferred from physical interaction	16241904	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in Harderian gland development	IMP IMP: Inferred from mutant phenotype	14623956	MGI
acts upstream of apoptotic process	IGI IGI: Inferred from genetic interaction	16207763	MGI
acts upstream of apoptotic process	IMP IMP: Inferred from mutant phenotype	16207763	MGI
acts upstream of or within embryonic camera-type eye development	IGI IGI: Inferred from genetic interaction	17184764	MGI
involved in embryonic camera-type eye development	IMP IMP: Inferred from mutant phenotype	14623956	MGI
acts upstream of or within embryonic eye morphogenesis	IGI IGI: Inferred from genetic interaction	16207763	MGI
acts upstream of or within embryonic eye morphogenesis	IMP IMP: Inferred from mutant phenotype	16207763	MGI
acts upstream of or within face development	IGI IGI: Inferred from genetic interaction	17184764	MGI
acts upstream of or within inner ear morphogenesis	IMP IMP: Inferred from mutant phenotype	23536097	MGI
acts upstream of or within locomotory behavior	IMP IMP: Inferred from mutant phenotype	23536097	MGI
acts upstream of or within neuromuscular process controlling balance	IMP IMP: Inferred from mutant phenotype	23536097	MGI
involved in nose development	IMP IMP: Inferred from mutant phenotype	14623956	MGI
acts upstream of or within nucleus accumbens development	IMP IMP: Inferred from mutant phenotype	17207476	MGI
acts upstream of or within olfactory pit development	IMP IMP: Inferred from mutant phenotype	17207476	MGI
acts upstream of or within optic cup morphogenesis involved in camera-type eye development	IGI IGI: Inferred from genetic interaction	16611695	MGI
acts upstream of or within positive regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	16207763	MGI
acts upstream of or within positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16207763	MGI
acts upstream of or within retinoic acid biosynthetic process	IDA IDA: Inferred from direct assay	11013254	MGI
involved in retinoic acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	14623956	MGI
acts upstream of or within retinoic acid metabolic process	IGI IGI: Inferred from genetic interaction	16207763	MGI
acts upstream of or within retinoic acid metabolic process	IMP IMP: Inferred from mutant phenotype	16207763	MGI
acts upstream of or within righting reflex	IMP IMP: Inferred from mutant phenotype	23536097	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16615129	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

aldehyde dehydrogenase family 1 member A3

RALDH-3	aldehyde dehydrogenase-6
retinaldehyde dehydrogenase 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W015273A	trans-3-Indoleacrylic acid	Inhibitor	99.39%	Unkown
HY-122912	ALDH1A inhibitor 673A		99.15%	Unkown
HY-135841	CM010	Inhibitor	99.70%	Unkown
HY-W017186	ALDH1A3-IN-3	Inhibitor	99.12%	Unkown
HY-125085	ALDH3A1-IN-3	Inhibitor	99.30%	Unkown
HY-144669	ALDH1A3-IN-2	Inhibitor	99.85%	Unkown
HY-144667	ALDH1A3-IN-1	Inhibitor	98.43%	Unkown
HY-164781	KOTX1	Inhibitor	98.94%	Unkown
HY-169884	MCI-INI-3	Inhibitor	≥99.0%	Unkown
HY-RS23346	Aldh1a3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-158026	ALDH1A1-IN-5	Inhibitor	/	Unkown
HY-159111	KS124		/	Unkown
HY-174209	CLM296	Inhibitor	/	Unkown
HY-RS00564	ALDH1A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-169883	PKM2-IN-7	Inhibitor	/	Unkown
HY-RS16904	Aldh1a3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aldh1a3	NCBI	NCBI:220

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