Gabarap - gamma-aminobutyric acid receptor associated protein Gene

Mus musculus

Gene ID: 56486 | Gene type: protein coding

About Gabarap

Summary

Enables microtubule binding activity. Acts upstream of or within microtubule Cytoskeleton organization. Located in several cellular components, including cytoskeleton; smooth endoplasmic reticulum; and sperm midpiece. Part of microtubule associated complex. Is expressed in retina inner plexiform layer and spinal cord. Orthologous to human GABARAP (GABA type A receptor-associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Gabarap Products(1)

mRNA	Protein	Name
NM_019749.4	NP_062723.1	gamma-aminobutyric acid receptor-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	10899939	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10900017	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within microtubule cytoskeleton organization	IDA IDA: Inferred from direct assay	10899939	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	EXP EXP: Inferred from Experiment	33436612	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	33436612	MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	33436612	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	33436612	MGI
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	33436612	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	33436612	MGI
located in Golgi apparatus	IDA IDA: Inferred from direct assay	11146101	MGI
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	10899939	MGI
located in axoneme	IDA IDA: Inferred from direct assay	24089209	MGI
located in lysosome	IDA IDA: Inferred from direct assay	11146101	MGI
part of microtubule associated complex	IDA IDA: Inferred from direct assay	10899939	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10900017	MGI
located in smooth endoplasmic reticulum	IDA IDA: Inferred from direct assay	11146101	MGI
located in sperm midpiece	IDA IDA: Inferred from direct assay	22033522	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

gamma-aminobutyric acid receptor-associated protein

GABA-A receptor-associated protein

gamma-aminobutyric acid reseptor associated protein

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16121	CAA-0225	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P5964A	K1 peptide TFA	Ligand	98.22%	Unkown
HY-168347	TH152	Ligand	/	Unkown
HY-P11208	mNLS-CPP-WSTF	Inhibitor	/	Unkown
HY-P5964	K1 peptide	Ligand	/	Unkown
HY-RS05201	GABARAP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17786	Gabarap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24253	Gabarap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gabarap	NCBI	NCBI:11337

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