Mtch2 - mitochondrial carrier 2 Gene

Mus musculus

Also known as HSPC032; 2310034D24Rik; 4930539J07Rik

Gene ID: 56428 | Gene type: protein coding

About Mtch2

Summary

This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]

Mtch2 Products(5)

mRNA	Protein	Name
NM_001317241.1	NP_001304170.1	mitochondrial carrier homolog 2 isoform 1x
NM_001317242.1	NP_001304171.1	mitochondrial carrier homolog 2 isoform 2
NM_001317243.1	NP_001304172.1	mitochondrial carrier homolog 2 isoform 3
NM_001317244.1	NP_001304173.1	mitochondrial carrier homolog 2 isoform 4
NM_019758.3	NP_062732.1	mitochondrial carrier homolog 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20436477	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to radiation	IMP IMP: Inferred from mutant phenotype	26219591	MGI
acts upstream of or within establishment of protein localization to mitochondrial membrane involved in mitochondrial fission	IMP IMP: Inferred from mutant phenotype	26219591	MGI
acts upstream of or within hematopoietic stem cell homeostasis	IMP IMP: Inferred from mutant phenotype	26219591	MGI
acts upstream of or within hematopoietic stem cell migration	IMP IMP: Inferred from mutant phenotype	26219591	MGI
acts upstream of or within hepatocyte apoptotic process	IGI IGI: Inferred from genetic interaction	20436477	MGI
acts upstream of or within lactate metabolic process	IMP IMP: Inferred from mutant phenotype	26219591	MGI
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	28127879	MGI
acts upstream of or within mitochondrial ATP synthesis coupled electron transport	IMP IMP: Inferred from mutant phenotype	26219591	MGI
acts upstream of or within negative regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	26219591	MGI
acts upstream of or within negative regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	26219591	MGI
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15899861	MGI
acts upstream of or within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	26219591	MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IMP IMP: Inferred from mutant phenotype	26219591	MGI
involved in positive regulation of stem cell differentiation	IMP IMP: Inferred from mutant phenotype	30510213	MGI
acts upstream of or within protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	20436477	MGI
involved in regulation of mitochondrial fusion	IMP IMP: Inferred from mutant phenotype	30510213	MGI
acts upstream of or within regulation of mitochondrial membrane permeability involved in apoptotic process	IGI IGI: Inferred from genetic interaction	20436477	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	20436477	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitochondrial carrier homolog 2

met-induced mitochondrial protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08755	MTCH2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19462	Mtch2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25955	Mtch2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mtch2	NCBI	NCBI:23788

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