2. Gene
  3. P3h1 - prolyl 3-hydroxylase 1 Gene

P3h1 - prolyl 3-hydroxylase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Gros1; Lepre1; 2410024C15Rik

Gene ID: 56401 | Gene type: protein coding

About P3h1

Summary

Predicted to enable procollagen-proline 3-dioxygenase activity. Acts upstream of or within Collagen fibril organization; negative regulation of cell growth; and regulation of ossification. Predicted to be located in basement membrane; cytoplasm; and nucleus. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; genitourinary system; limb mesenchyme; sensory organ; and skeleton. Used to study osteogenesis imperfecta type 8. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 8. Orthologous to human P3H1 (prolyl 3-hydroxylase 1). [provided by Alliance of Genome Resources, Apr 2022]

P3h1 Products(4)

mRNA Protein Name
NM_001042411.1 NP_001035874.1 prolyl 3-hydroxylase 1 isoform 3
NM_001286148.1 NP_001273077.1 prolyl 3-hydroxylase 1 isoform 4 precursor
NM_019782.3 NP_062756.2 prolyl 3-hydroxylase 1 isoform 1 precursor
NM_019783.2 NP_062757.2 prolyl 3-hydroxylase 1 isoform 2 precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within collagen fibril organization IMP
IMP: Inferred from mutant phenotype
20363744 MGI
acts upstream of or within negative regulation of cell growth IDA
IDA: Inferred from direct assay
10951563 MGI
acts upstream of or within regulation of ossification IMP
IMP: Inferred from mutant phenotype
20363744 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolyl 3-hydroxylase 1

growth suppressor 1

leprecan 1

leucine- and proline-enriched proteoglycan 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16280 FAM-labeled P3H1 Human Pre-designed siRNA Set A / Unkown
HY-RS09938 P3H1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20791 P3h1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS27305 P3h1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P3h1 NCBI NCBI:64175