Tmed2 - transmembrane p24 trafficking protein 2 Gene

Mus musculus

Also known as Rnp24; Sid394; p24beta1; 1110032D12Rik; 1810020N21Rik

Gene ID: 56334 | Gene type: protein coding

About Tmed2

Summary

Involved in embryonic morphogenesis; labyrinthine layer blood vessel development; and maternal placenta development. Acts upstream of or within several processes, including PERK-mediated unfolded protein response; chordate embryonic development; and regulation of gene expression. Located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including cardiovascular system; early conceptus; embryo ectoderm; placenta; and trunk mesenchyme. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Tmed2 Products(6)

mRNA	Protein	Name
NM_001403253.1	NP_001390182.1	transmembrane emp24 domain-containing protein 2 isoform 1 precursor
NM_001403257.1	NP_001390186.1	transmembrane emp24 domain-containing protein 2 isoform 3
NM_019770.3	NP_062744.1	transmembrane emp24 domain-containing protein 2 isoform 2 precursor
NM_001403253.1	NP_001390182.1	transmembrane emp24 domain-containing protein 2 isoform 1 precursor
NM_001403257.1	NP_001390186.1	transmembrane emp24 domain-containing protein 2 isoform 3
NM_019770.3	NP_062744.1	transmembrane emp24 domain-containing protein 2 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables frizzled binding	IPI IPI: Inferred from physical interaction	35353806	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	31040128	MGI
enables smoothened binding	IPI IPI: Inferred from physical interaction	35353806	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within PERK-mediated unfolded protein response	IMP IMP: Inferred from mutant phenotype	28797121	MGI
acts upstream of or within allantois development	IMP IMP: Inferred from mutant phenotype	30236446	MGI
acts upstream of or within branching involved in labyrinthine layer morphogenesis	IMP IMP: Inferred from mutant phenotype	30236446	MGI
acts upstream of or within chorion development	IMP IMP: Inferred from mutant phenotype	30236446	MGI
involved in embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within embryonic placenta development	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within endoplasmic reticulum membrane organization	IMP IMP: Inferred from mutant phenotype	28797121	MGI
acts upstream of or within endoplasmic reticulum organization	IMP IMP: Inferred from mutant phenotype	30236446	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	31040128	MGI
involved in labyrinthine layer blood vessel development	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within maintenance of protein localization in organelle	IMP IMP: Inferred from mutant phenotype	35353806	MGI
involved in maternal placenta development	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation	IMP IMP: Inferred from mutant phenotype	28797121	MGI
acts upstream of or within negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	35353806	MGI
acts upstream of or within negative regulation of smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	35353806	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	30236446	MGI
acts upstream of or within protein secretion	IMP IMP: Inferred from mutant phenotype	31040128	MGI
acts upstream of or within regulation of SREBP signaling pathway	IMP IMP: Inferred from mutant phenotype	28797121	MGI
acts upstream of or within somite rostral/caudal axis specification	IMP IMP: Inferred from mutant phenotype	20178780	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	20178780	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Golgi apparatus	IDA IDA: Inferred from direct assay	35353806	MGI
located in Golgi apparatus	IDA IDA: Inferred from direct assay	35353806	MGI
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	30236446	MGI
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	30236446	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transmembrane emp24 domain-containing protein 2

COPI-coated vesicle membrane protein p24	Sid394p
coated vesicle membrane protein	membrane protein p24A
p24 family protein beta-1	sid 394
transmembrane emp24 domain trafficking protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14636	TMED2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21788	Tmed2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tmed2	NCBI	NCBI:10959

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