Tgm2 - transglutaminase 2 Gene

Rattus norvegicus

Also known as tTG; TgaseII

Gene ID: 56083 | Gene type: protein coding

About Tgm2

Summary

Enables GTP binding activity; identical protein binding activity; and protein domain specific binding activity. Involved in several processes, including isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of cytosolic calcium ion concentration involved in Phospholipase C-activating G protein-coupled signaling pathway. Acts upstream of or within Phospholipase C-activating G protein-coupled receptor signaling pathway. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Orthologous to human TGM2 (Transglutaminase 2). [provided by Alliance of Genome Resources, Apr 2022]

Tgm2 Products(1)

mRNA	Protein	Name
NM_019386.3	NP_062259.3	protein-glutamine gamma-glutamyltransferase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	14970202	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	12469910	RGD
enables phospholipase binding	IPI IPI: Inferred from physical interaction	16709602	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	12054611	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel remodeling	IMP IMP: Inferred from mutant phenotype	15550691	RGD
involved in isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine	IDA IDA: Inferred from direct assay	16341586	RGD
acts upstream of or within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	7911253	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	11073883	RGD
involved in positive regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	15471861	RGD
involved in positive regulation of smooth muscle cell proliferation	IDA IDA: Inferred from direct assay	14970202	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	7911253	RGD
located in cytosol	IDA IDA: Inferred from direct assay	11073883	RGD
located in nucleus	IDA IDA: Inferred from direct assay	11073883	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein-glutamine gamma-glutamyltransferase 2

TGase 2	TGase II
glutamine gamma-glutamyltransferase 2	isopeptidase TGM2
protein G alpha(h)	protein G(h)
protein-glutamine deamidase TGM2	protein-glutamine dopaminyltransferase TGM2
protein-glutamine histaminyltransferase TGM2	protein-glutamine n

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-117678	TG-2-IN-1	Inhibitor	≥98.0%	Unkown
HY-12589	ZM39923 hydrochloride	Inhibitor	98.19%	Unkown
HY-RS14459	TGM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-12589A	ZM39923	Inhibitor	/	Unkown
HY-RS16889	Tgm2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23331	Tgm2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgm2	NCBI	NCBI:7052
Mus musculus	Tgm2	NCBI	NCBI:21817

Name
Email *

	Sorry, but the email address you supplied was invalid.