Nptn - neuroplastin Gene

Rattus norvegicus

Also known as SDR-1; Sdfr1

Gene ID: 56064 | Gene type: protein coding

About Nptn

Summary

Enables cell adhesion molecule binding activity; transmembrane transporter binding activity; and type 1 Fibroblast Growth Factor receptor binding activity. Involved in several processes, including homophilic cell adhesion via plasma membrane adhesion molecules; positive regulation of signal transduction; and regulation of synaptic plasticity. Located in several cellular components, including inhibitory synapse; postsynaptic density; and presynaptic membrane. Is active in several cellular components, including GABA-ergic synapse; Schaffer collateral - CA1 synapse; and glutamatergic synapse. Is integral component of postsynaptic density membrane and integral component of presynaptic active zone membrane. Orthologous to human NPTN (neuroplastin). [provided by Alliance of Genome Resources, Apr 2022]

Nptn Products(4)

mRNA	Protein	Name
NM_001413347.1	NP_001400276.1	neuroplastin isoform 1 precursor
NM_001413348.1	NP_001400277.1	neuroplastin isoform 3 precursor
NM_001413349.1	NP_001400278.1	neuroplastin isoform 4 precursor
NM_019380.3	NP_062253.1	neuroplastin isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion molecule binding	IDA IDA: Inferred from direct assay	10759566	RGD
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	22389504	RGD
enables type 1 fibroblast growth factor receptor binding	IDA IDA: Inferred from direct assay	19952283	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	10759566	RGD
involved in long-term synaptic potentiation	IDA IDA: Inferred from direct assay	16925595	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	19952283	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	19952283	RGD
involved in positive regulation of fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	19952283	RGD
involved in positive regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	10759566	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	10759566	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	19952283	RGD
involved in positive regulation of protein localization	IMP IMP: Inferred from mutant phenotype	22389504	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	16925595	RGD
involved in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	EXP EXP: Inferred from Experiment	10759566	RGD
involved in trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission	IDA IDA: Inferred from direct assay	10759566	RGD
involved in visual learning	IDA IDA: Inferred from direct assay	21480899	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	23622064	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	22389504	RGD
is active in Schaffer collateral - CA1 synapse	EXP EXP: Inferred from Experiment	10759566	RGD
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	10759566	RGD
located in cell surface	IDA IDA: Inferred from direct assay	10759566	RGD
located in dendrite	IDA IDA: Inferred from direct assay	22389504	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	23622064	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	23622064	RGD
located in inhibitory synapse	IDA IDA: Inferred from direct assay	22389504	RGD
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	3224275	RGD
is active in presynaptic active zone membrane	EXP EXP: Inferred from Experiment	23622064	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	23622064	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	11431460	RGD
is active in synaptic membrane	IDA IDA: Inferred from direct assay	22389504	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	1573391	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuroplastin

glycoprotein 55	glycoprotein 55/65
glycoprotein 65	gp55/65
stromal cell derived factor receptor 1	stromal cell-derived receptor 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09504	NPTN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19925	Nptn Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26427	Nptn Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nptn	NCBI	NCBI:27020

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