TRIT1 - tRNA isopentenyltransferase 1 Gene

Homo sapiens

Also known as IPT; GRO1; IPPT; MOD5; hGRO1; IPTase; COXPD35

Gene ID: 54802 | Gene type: protein coding

About TRIT1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,838,110-39,883,511 (from NCBI)

This gene has 16 transcripts (splice variants), 216 orthologues and is associated with 2 phenotypes. Ubiquitous expression in thyroid (RPKM 7.3), prostate (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]

TRIT1 Products(3)

mRNA	Protein	Name
NM_001312691.1	NP_001299620.1	tRNA dimethylallyltransferase isoform 2
NM_001312692.1	NP_001299621.1	tRNA dimethylallyltransferase isoform 3
NM_017646.6	NP_060116.2	tRNA dimethylallyltransferase isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables tRNA dimethylallyltransferase activity	EXP EXP: Inferred from Experiment	24901367	GOA
enables tRNA dimethylallyltransferase activity	IDA IDA: Inferred from direct assay	24126054	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitochondrial tRNA modification	IDA IDA: Inferred from direct assay	24901367	GOA
involved in tRNA modification	IDA IDA: Inferred from direct assay	24126054	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in mitochondrion	IDA IDA: Inferred from direct assay	24901367	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIT1 Protein Structure

IPPT

zf-C2H2_jaz

0
100
200
300
400
467 a.a.

Protein Preferred Names

Protein Names

tRNA dimethylallyltransferase

IPP transferase

Related Diseases

Diseases

Alias

Combined Oxidative Phosphorylation Deficiency 35

COXPD35

Combined Oxidative Phosphorylation Deficiency

Sideroblastic Anemia With B-Cell Immunodeficiency, Periodic Fevers, And Developmental Delay

SIFD	Congenital Sideroblastic Anemia-B-Cell Immunodeficiency-Periodic Fever-Developmental Delay Syndrome
Sifd Syndrome

Cardiomyopathy, Infantile Hypertrophic

Infantile Hypertrophic Cardiomyopathy

CMHI

Early Myoclonic Encephalopathy

Myoclonic Epilepsy	Myoclonic Seizure
Epilepsies, Myoclonic	Epileptic Seizures - Myoclonic
Epileptic Seizures, Myoclonic	Myoclonia Epileptica
Myoclonic Seizure Disorder	Early Myoclonic Encephalopathy With Suppression-Bursts

Frontometaphyseal Dysplasia

Fmd	Dysplasia, Frontometaphyseal

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Non-Syndromic X-Linked Intellectual Disability

X-Linked Non-Syndromic Intellectual Disability	Non-Specific X-Linked Mental Retardation
X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15084	TRIT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRIT1	RGD	RGD:1304781
Canis familiaris	TRIT1	VGNC	VGNC:47848
Macaca mulatta	TRIT1	VGNC	VGNC:79239
Mus musculus	TRIT1	MGD	MGI:1914216
Felis catus	TRIT1	VGNC	VGNC:66563
Bos taurus	TRIT1	VGNC	VGNC:36363

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