1. Gene
  2. Egln3 - egl-9 family hypoxia-inducible factor 3 Gene

Egln3 - egl-9 family hypoxia-inducible factor 3 Gene

Rattus norvegicus

Also known as PHD3; PHD-3; SM-20

Gene ID: 54702 | Gene type: protein coding

About Egln3

Summary

Predicted to enable ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Involved in regulation of cell population proliferation. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Biomarker of acute kidney failure and myocardial infarction. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN3 (egl-9 family hypoxia inducible factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Egln3 Products(1)

mRNA Protein Name
NM_019371.2 NP_062244.2 prolyl hydroxylase EGLN3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20849813 RGD
Biological Process GO Annotation Evidence Reference Source
involved in regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
12379765 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

prolyl hydroxylase EGLN3

HIF-PH3

HIF-prolyl hydroxylase 3

HPH-3

egl nine homolog 3, mitochondrial

factor-responsive smooth muscle protein

hypoxia-inducible factor prolyl hydroxylase 3

prolyl hydroxylase domain-containing protein 3

Orthologs Information

Species Symbol Source ID
Homo sapiens Egln3 NCBI NCBI:112399