Syt7 - synaptotagmin VII Gene

Mus musculus

Also known as B230112P13Rik

Gene ID: 54525 | Gene type: protein coding

About Syt7

Summary

Enables SNARE binding activity; Calmodulin binding activity; and phospholipid binding activity. Involved in several processes, including calcium-ion regulated exocytosis; regulation of secretion by cell; and regulation of vesicle-mediated transport. Acts upstream of or within plasma membrane repair. Located in several cellular components, including GABA-ergic synapse; cytoplasmic vesicle; and presynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SYT7 (synaptotagmin 7). [provided by Alliance of Genome Resources, Apr 2022]

Syt7 Products(4)

mRNA	Protein	Name
NM_001373944.1	NP_001360873.1	synaptotagmin-7 isoform 4
NM_018801.3	NP_061271.1	synaptotagmin-7 isoform alpha
NM_173067.3	NP_775090.1	synaptotagmin-7 isoform beta
NM_173068.2	NP_775091.2	synaptotagmin-7 isoform gamma

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IDA IDA: Inferred from direct assay	12860971	MGI
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	16982801	MGI
enables calmodulin binding	IDA IDA: Inferred from direct assay	24569478	MGI
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	12860971	MGI
enables phosphatidylserine binding	IDA IDA: Inferred from direct assay	12860971	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21041449	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion regulated lysosome exocytosis	IMP IMP: Inferred from mutant phenotype	16982801	MGI
involved in calcium ion-regulated exocytosis of neurotransmitter	IMP IMP: Inferred from mutant phenotype	26738595	MGI
involved in calcium-dependent activation of synaptic vesicle fusion	IDA IDA: Inferred from direct assay	24267651	MGI
involved in calcium-dependent activation of synaptic vesicle fusion	IMP IMP: Inferred from mutant phenotype	24267651	MGI
involved in phagocytosis	IMP IMP: Inferred from mutant phenotype	21041449	MGI
involved in phagosome-lysosome fusion	IMP IMP: Inferred from mutant phenotype	16982801	MGI
acts upstream of or within plasma membrane repair	IDA IDA: Inferred from direct assay	12925704	MGI
involved in regulation of bone remodeling	IMP IMP: Inferred from mutant phenotype	18539119	MGI
involved in regulation of calcium ion-dependent exocytosis	IMP IMP: Inferred from mutant phenotype	12860971	MGI
involved in regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	21576241	MGI
involved in regulation of glucagon secretion	IMP IMP: Inferred from mutant phenotype	19171650	MGI
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	18308938	MGI
involved in regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	16982801	MGI
involved in short-term synaptic potentiation	IDA IDA: Inferred from direct assay	26738595	MGI
involved in short-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	24569478	MGI
involved in synaptic vesicle recycling	IMP IMP: Inferred from mutant phenotype	24569478	MGI
involved in vesicle-mediated cholesterol transport	IDA IDA: Inferred from direct assay	25860611	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	24267651	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	24267651	MGI
located in axon terminus	IDA IDA: Inferred from direct assay	21576241	MGI
located in dendrite	IDA IDA: Inferred from direct assay	21576241	MGI
located in early phagosome	IDA IDA: Inferred from direct assay	16982801	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24267651	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24267651	MGI
located in lysosome	IDA IDA: Inferred from direct assay	12925704	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	21576241	MGI
located in peroxisome	IDA IDA: Inferred from direct assay	25860611	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	11395007	MGI
located in synaptic vesicle	IMP IMP: Inferred from mutant phenotype	24569478	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptotagmin-7

sytVII

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14119	SYT7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20823	Syt7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27337	Syt7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syt7	NCBI	NCBI:9066

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