Stk39 - serine threonine kinase 39 Gene

Rattus norvegicus

Also known as Spak

Gene ID: 54348 | Gene type: protein coding

About Stk39

Summary

Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in positive regulation of ion transport; positive regulation of p38MAPK cascade; and protein autophosphorylation. Located in Cytoskeleton and cytosol. Is extrinsic component of membrane. Orthologous to human STK39 (serine/threonine kinase 39). [provided by Alliance of Genome Resources, Apr 2022]

Stk39 Products(1)

mRNA	Protein	Name
NM_019362.1	NP_062235.1	STE20/SPS1-related proline-alanine-rich protein kinase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase activity	IMP IMP: Inferred from mutant phenotype	12740379	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12740379	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	16083423	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	10980603	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of ion transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	12740379	RGD
involved in positive regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	10980603	RGD
involved in positive regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	19307180	RGD
involved in protein autophosphorylation	IMP IMP: Inferred from mutant phenotype	10980603	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10980603	RGD
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	12740379	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell cortex	IDA IDA: Inferred from direct assay	25515571	RGD
located in cytosol	IDA IDA: Inferred from direct assay	25515571	RGD
located in cytosol	IMP IMP: Inferred from mutant phenotype	10980603	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

STE20/SPS1-related proline-alanine-rich protein kinase

PS/TK	PSTK1
Ste-20 related kinase	pancreatic serine/threonine-protein kinase
serine/threonine-protein kinase 39	ste-20-related kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13940	STK39 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21058	Stk39 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27575	Stk39 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stk39	NCBI	NCBI:27347

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