Eif2s1 - eukaryotic translation initiation factor 2 subunit alpha Gene

Rattus norvegicus

Gene ID: 54318 | Gene type: protein coding

About Eif2s1

Summary

Predicted to enable ribosome binding activity and translation initiation factor activity. Involved in several processes, including negative regulation of guanyl-nucleotide exchange factor activity; positive regulation of cell death; and response to manganese-induced endoplasmic reticulum stress. Located in cytoplasm; glial limiting end-foot; and nucleus. Part of eukaryotic translation initiation factor 2 complex and translation initiation ternary complex. Used to study middle cerebral artery infarction. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Eif2s1 Products(1)

mRNA	Protein	Name
NM_019356.1	NP_062229.1	eukaryotic translation initiation factor 2 subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	2450747	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to heat	IDA IDA: Inferred from direct assay	7930798	RGD
involved in cellular response to heat	IEP IEP: Inferred from expression pattern	3500171	RGD
involved in negative regulation of guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	9582312	RGD
involved in positive regulation of type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	17158450	RGD
involved in response to kainic acid	IEP IEP: Inferred from expression pattern	17251432	RGD
involved in response to manganese-induced endoplasmic reticulum stress	IEP IEP: Inferred from expression pattern	23934647	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of eukaryotic translation initiation factor 2 complex	IDA IDA: Inferred from direct assay	2450747	RGD
located in glial limiting end-foot	IDA IDA: Inferred from direct assay	9397028	RGD
part of translation initiation ternary complex	IDA IDA: Inferred from direct assay	2450747	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eukaryotic translation initiation factor 2 subunit 1

EIF-2A	EIF-2alpha
eIF-2-alpha	eukaryotic translation initiation factor 2 subunit 1 alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04254	EIF2S1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21851	Eif2s1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28368	Eif2s1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eif2s1	NCBI	NCBI:1965

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