Ncor1 - nuclear receptor co-repressor 1 Gene

Rattus norvegicus

Also known as Rxrip13

Gene ID: 54299 | Gene type: protein coding

About Ncor1

Summary

Enables several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; nuclear receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in animal organ development; negative regulation of macromolecule metabolic process; and positive regulation of cell population proliferation. Located in nucleus and perinuclear region of cytoplasm. Used to study anxiety disorder and polycystic ovary syndrome. Biomarker of hypothyroidism and polycystic ovary syndrome. Orthologous to human NCOR1 (nuclear receptor corepressor 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncor1 Products(1)

mRNA	Protein	Name
NM_001271103.1	NP_001258032.1	nuclear receptor corepressor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17079677	RGD
enables chromatin binding	IDA IDA: Inferred from direct assay	20352046	RGD
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	17079677	RGD
enables nuclear estrogen receptor binding	IPI IPI: Inferred from physical interaction	19460436	RGD
enables nuclear retinoic acid receptor binding	IPI IPI: Inferred from physical interaction	15234273	RGD
enables nuclear retinoid X receptor binding	IPI IPI: Inferred from physical interaction	15234273	RGD
enables peroxisome proliferator activated receptor binding	IPI IPI: Inferred from physical interaction	15870285	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10441327	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10441327	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebellum development	IEP IEP: Inferred from expression pattern	10803578	RGD
involved in lactation	IEP IEP: Inferred from expression pattern	15946693	RGD
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	9139820	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19608741	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	19608741	RGD
involved in skeletal muscle tissue development	IEP IEP: Inferred from expression pattern	9839950	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19696011	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear receptor corepressor 1

N-CoR	N-CoR1
N-Cor/SMRT corepressor, Rip13	NCoR

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121900	LT175	Agonist	99.79%	Unkown
HY-RS09096	NCOR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20452	Ncor1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26961	Ncor1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncor1	NCBI	NCBI:9611

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