PRKG1 - Prkg1 protein kinase cGMP-dependent 1 Gene

Rattus norvegicus

Also known as Pkgi; cGk1

Gene ID: 54286 | Gene type: protein coding

About PRKG1

Summary

Enables identical protein binding activity and mitogen-activated protein kinase p38 binding activity. Involved in several processes, including cell growth involved in cardiac muscle cell development; regulation of cellular biosynthetic process; and regulation of ion transport. Located in several cellular components, including Golgi apparatus; acrosomal vesicle; and nucleoplasm. Colocalizes with sarcolemma. Biomarker of allergic rhinitis; hypertension; hypogonadism; impotence; and obesity. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Apr 2022]

PRKG1 Products(1)

mRNA	Protein	Name
NM_001105731.4	NP_001099201.3	cGMP-dependent protein kinase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	23454089	RGD
enables mitogen-activated protein kinase p38 binding	IDA IDA: Inferred from direct assay	16943189	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	19542178	RGD
involved in cerebellum development	IEP IEP: Inferred from expression pattern	15763176	RGD
involved in heart development	IEP IEP: Inferred from expression pattern	2792381	RGD
involved in negative regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	10081919	RGD
involved in negative regulation of inositol phosphate biosynthetic process	IMP IMP: Inferred from mutant phenotype	7535379	RGD
involved in negative regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	15576431	RGD
involved in positive regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	12930792	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	8706897	RGD
involved in positive regulation of large conductance calcium-activated potassium channel activity	IMP IMP: Inferred from mutant phenotype	23407708	RGD
involved in regulation of testosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	22429315	RGD
involved in spermatid development	IEP IEP: Inferred from expression pattern	15713832	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	8719784	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	15713832	RGD
located in nucleoplasm	IDA IDA: Inferred from direct assay	18474265	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	12855709	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cGMP-dependent protein kinase 1

cAMP-dependent protein kinase catalytic subunit PRKX-like	cGMP dependent protein kinase type 1
protein kinase, cGMP-dependent, type 1	protein kinase, cGMP-dependent, type I

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11154	PRKG1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20087	Prkg1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26590	Prkg1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	PRKG1	NCBI	NCBI:5592

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