2. Gene
  3. Rfx5 - regulatory factor X, 5 (influences HLA class II expression) Gene

Rfx5 - regulatory factor X, 5 (influences HLA class II expression) Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 53970 | Gene type: protein coding

About Rfx5

Summary

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; eye; genitourinary system; heart; and nervous system. Human ortholog(s) of this gene implicated in MHC class II deficiency and severe combined immunodeficiency. Orthologous to human RFX5 (regulatory factor X5). [provided by Alliance of Genome Resources, Apr 2022]

Rfx5 Products(13)

mRNA Protein Name
NM_001025601.2 NP_001020772.2 DNA-binding protein Rfx5 isoform 3
NM_001355705.2 NP_001342634.1 DNA-binding protein Rfx5 isoform 1
NM_001355706.2 NP_001342635.1 DNA-binding protein Rfx5 isoform 2
NM_001355707.2 NP_001342636.1 DNA-binding protein Rfx5 isoform 3
NM_001410649.1 NP_001397578.1 DNA-binding protein Rfx5 isoform 1
NM_001410650.1 NP_001397579.1 DNA-binding protein Rfx5 isoform 1
NM_001410651.1 NP_001397580.1 DNA-binding protein Rfx5 isoform 1
NM_001410652.1 NP_001397581.1 DNA-binding protein Rfx5 isoform 2
NM_001410653.1 NP_001397582.1 DNA-binding protein Rfx5 isoform 2
NM_001410654.1 NP_001397583.1 DNA-binding protein Rfx5 isoform 3
NM_001410655.1 NP_001397584.1 DNA-binding protein Rfx5 isoform 3
NM_001410656.1 NP_001397585.1 DNA-binding protein Rfx5 isoform 3
NM_017395.4 NP_059091.2 DNA-binding protein Rfx5 isoform 1
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
16254146 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA-binding protein Rfx5

regulatory factor X 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS11883 RFX5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS22301 Rfx5 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rfx5 NCBI NCBI:5993